Serum concentration of AMDL DR-70 for the diagnosis and prognosis of carcinoma of the tongue

Li, Xiaodan; Qiao, Zhi; Long, Xing; Wei, Jinxiong; Cheng, Yong

doi:10.1016/j.bjoms.2004.11.020

« Previous Next »British Journal of Oral and Maxillofacial Surgery
Volume 43, Issue 6 , Pages 513-515, December 2005

Serum concentration of AMDL DR-70 for the diagnosis and prognosis of carcinoma of the tongue

Xiaodan Li
- Department of Oral Maxillofacial Surgery, College of Stomatology, Wuhan University, Key Laboratory for Oral Biomedical Engineering, Ministry of Education, Wuhan, Hubei 430079, PR China
Zhi Qiao
- Department of Microbiology, College of Medicine, Wuhan University, PR China
Xing Long
- Department of Oral Maxillofacial Surgery, College of Stomatology, Wuhan University, Key Laboratory for Oral Biomedical Engineering, Ministry of Education, Wuhan, Hubei 430079, PR China
- Corresponding author. Tel.: +86 27 876 46312; fax: +86 27 878 73260.
Jinxiong Wei
- Department of Oral Maxillofacial Surgery, College of Stomatology, Wuhan University, Key Laboratory for Oral Biomedical Engineering, Ministry of Education, Wuhan, Hubei 430079, PR China
Yong Cheng
- Department of Oral Maxillofacial Surgery, College of Stomatology, Wuhan University, Key Laboratory for Oral Biomedical Engineering, Ministry of Education, Wuhan, Hubei 430079, PR China

Received 15 December 2003; accepted 13 November 2004.

Abstract

The aim of this study was to discover the clinical value of the tumour marker AMDL DR-70 in a group of patients with cancer of the tongue. Serum concentrations of AMDL DR-70 were estimated by enzyme linked immuno-sorbent assay in 52 patients with carcinoma of the tongue and compared with 40 controls and 42 patients with benign lesions in the tongue. Thirty-nine patients with carcinoma of the tongue had results above 6mg/L (75%), compared with 3/40 (7%) in healthy controls and 4/42 (10%) in those with benign tumours. The concentration of AMDL DR-70 in serum correlated significantly with 3-year survival.