British Journal of Oral and Maxillofacial Surgery
Volume 45, Issue 3 , Pages 203-207, April 2007

Quantitative morphometric evaluation of critical size experimental bone defects by microcomputed tomography

  • Candan Efeoglu

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Level 6 Worsley Building, Leeds Dental Institute, Clarendon Way, Leeds, West Yorkshire LS2 9LU, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 113 3436165.
    • ,
  • Sheila E. Fisher

      Affiliations

    • Department of Maxillofacial Surgery, Faculty of Medicine and Health, University of Leeds, UK
    • ,
  • Selda Ertürk

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey
    • ,
  • Fikri Öztop

      Affiliations

    • Department of Pathology, School of Medicine, Ege University, Izmir, Turkey
    • ,
  • Sevtap Günbay

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey
    • ,
  • Aylin Sipahi

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey

Accepted 27 May 2006. published online 20 July 2006.

Abstract 

Our aim was to show that microcomputed tomography is a useful tool for acquiring high-resolution three-dimensional tomographic images to assess bone healing, the interface with materials, and the biocompatibility of bone substitutes. Acquired images can be used for non-invasive quantitative morphometric analysis of regenerating bone, leaving the option for conventional histology to be an adjunct used at defined intervals.

The temporal characterisation of the mineralisation of bone potentially has a critical role in the understanding of the dynamics of mineralisation of healing bone. This has applications both for degradable and bioactive materials and for pharmaceutical products that act on bone. Formal validation of this promising new technique will be a critical part of continuing studies.

Keywords: Microcomputed tomography, Histomorphometrics, Critical size bone defect, Quantitative morphometrics

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PII: S0266-4356(06)00101-X

doi:10.1016/j.bjoms.2006.05.007

British Journal of Oral and Maxillofacial Surgery
Volume 45, Issue 3 , Pages 203-207, April 2007

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