British Journal of Oral and Maxillofacial Surgery
Volume 45, Issue 3 , Pages 203-207 , April 2007

Quantitative morphometric evaluation of critical size experimental bone defects by microcomputed tomography

  • Candan Efeoglu

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Level 6 Worsley Building, Leeds Dental Institute, Clarendon Way, Leeds, West Yorkshire LS2 9LU, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 113 3436165.
  • ,
  • Sheila E. Fisher

      Affiliations

    • Department of Maxillofacial Surgery, Faculty of Medicine and Health, University of Leeds, UK
  • ,
  • Selda Ertürk

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey
  • ,
  • Fikri Öztop

      Affiliations

    • Department of Pathology, School of Medicine, Ege University, Izmir, Turkey
  • ,
  • Sevtap Günbay

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey
  • ,
  • Aylin Sipahi

      Affiliations

    • Department of Oral Surgery, School of Dentistry, Ege University, Izmir, Turkey

,Accepted 27 May 2006.

References 

  1. Hilderbrand T, Laib A, Müller R, Dequeker J, Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calceneus. J Bone Miner Res. 1999;14:1167–1175
  2. Kurth AA, Müller R. The effect of an osteolithic tumor on the three-dimensional trabecular bone morphology in an animal model. Skeletal Radiol. 2001;30:94–98
  3. Muller R, Van Campenhout H, Van Damme B, et al. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone. 1998;23:59–66
  4. Odgaard Agundersen HJ. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. 1993;14:173–182
  5. Rüegsegger P, Koller B, Muller R. A microtomographic system for the non-destructive evaluation of bone architecture. Calcif Tiss Int. 1996;58:24–29
  6. Efeoglu C, Delen Akçay Y, Ertϋrk S. A modified method for preparing platelet rich plasma: an experimental study. J Oral Maxillofac Surg. 2004;62:1403–1407
  7. Beck L, Deguzman L, Lee W. Rapid publication. TGF-beta 1 induces bone closure of skull defects. J Bone Miner Res. 1991;6:1257–1265
  8. Frame JW. A convenient animal model for testing bone substitute materials. J Oral Surg. 1980;38:176–180
  9. Kim ES, Park EJ, Choung PH. Platelet concentration and its effect on bone formation in calvarial defects: an experimental study in rabbits. J Prosthet Dent. 2001;86:428–433
  10. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Relat Res. 1986;205:299–308
  11. Vikjaer D, Blom S, Hjorting-Hansen E, Pinholt EM. Effect of platelet-derived growth factor-bb on bone formation in calvarial defects: an experimental study in rabbits. Eur J Oral Sci. 1997;105:59–66
  12. Zellin G, Beck S, Hardwick R, Linde A. Opposite effects of recombinant human transforming growth factor beta1 on bone regeneration in vivo: effects of exclusion of periosteal cells by microporous membrane. Bone. 1998;22:613–620
  13. Cacciafesta V, Dalstra M, Bosch C, Melsen B, Andreassen TT. Growth hormone treatment promotes guided bone regeneration in rat calvarial defects. Eur J Orthod. 2001;23:733–740
  14. Gowen M, Lazner F, Dodds R, et al. Cathepsin K knockout mice develop osteoporosis due to a deficit in matrix degradation but not demineralization. J Bone Miner Res. 1999;14:1654–1663
  15. Lutolf MP, Weber FE, Schmoekel HG, et al. Repair of bone defects using synthetic mimetics of collageneous extracellular matrices. Nat Biotechnol. 2003;21:513–518Epub 2003 April 21. doi:10.1038/nbt818
  16. Verna C, Dalstra M, Wikesjö UM, Trombelli L, Bosch Carles. Healing patterns in calvarial bone defects following guided bone regeneration in rats. A micro-CT scan analysis. J Clin Periodontol. 2002;29:865–870
  17. Jones AC, Sakellariou A, Limaye A, et al. Investigation of microstructural features in regenerating bone using microcomputed tomography. J Mater Sci Mater Med. 2004;15:529–532
  18. Lu M, Rabie ABM. Microarchitecture of rabbit mandibular defects grafted with intramembraneous or endochondral bone shown by microcomputed tomography. Br J Oral Maxillofac Surg. 2003;41:385–391

PII: S0266-4356(06)00101-X

doi: 10.1016/j.bjoms.2006.05.007

British Journal of Oral and Maxillofacial Surgery
Volume 45, Issue 3 , Pages 203-207 , April 2007