British Journal of Oral and Maxillofacial Surgery
Volume 47, Issue 8 , Pages 616-621 , December 2009

Analysis of calvarial bone defects in rats using microcomputed tomography: potential for a novel composite material and a new quantitative measurement

  • Candan Efeoglu

      Affiliations

    • Oral and Maxillofacial Surgery, Leeds Dental Institute, University of Leeds, UK
    • Corresponding Author InformationCorresponding author at: ADCH Cerrahisi AD, School of Dentistry, Ege University, Bornova-Izmir 35100, Turkey. Tel.: +90 232 3881108; fax: +90 232 3398289.
    • ,
  • Julie L. Burke

      Affiliations

    • Oral and Maxillofacial Surgery, Leeds Dental Institute, University of Leeds, UK
    • ,
  • Andrew J. Parsons

      Affiliations

    • University of Nottingham, UK
    • ,
  • Graham A. Aitchison

      Affiliations

    • University of Nottingham, UK
    • ,
  • Colin Scotchford

      Affiliations

    • University of Nottingham, UK
    • ,
  • Chris Rudd

      Affiliations

    • University of Nottingham, UK
    • ,
  • Aditya Vikram

      Affiliations

    • University of Leeds, UK
    • ,
  • Sheila E. Fisher

      Affiliations

    • University of Bradford, UK

,Accepted 23 February 2009.

References 

  1. Alexander R, Theodos L. Fracture of the bone-grafted mandible secondary to stress shielding: report of a case and review of the literature. J Oral Maxillofac Surg. 1993;51:695–697
  2. Kim YR, Yeo HH, Lim SC. Tissue response to titanium plates: a transmitted electron microscopic study. J Oral Maxillofac Surg. 1997;55:322–326
  3. Christian P, Jones IA. Polymerisation and stabilisation of polycaprolactone using a borontrifluoride-glycerol catalyst system. Polymer. 2001;42:3989–3994
  4. Christian P, Jones IA, Rudd CD, Campbell R, Corden TJ. Monomer transfer moulding and rapid prototyping methods for fibre-reinforced thermoplastics for medical applications. Compos. A Appl. Sci. Manuf. 2001;32:969–976
  5. Corden TJ, Jones IA, Rudd CD, Christian P, Downes S, McDougall KE. Physical and biocompatibility properties of poly-epsilon-caprolactone produced using in situ polymerisation: a novel manufacturing technique for long fibre composite materials. Biomaterials. 2000;21:713–724
  6. Gough JE, Christian P, Scotchford CA, Rudd CD, Jones IA. Synthesis, degradation, and in vitro cell responses of sodium phosphate glasses for craniofacial bone repair. J Biomed Mater Res. 2002;59:481–489
  7. Gough JE, Christian P, Scotchford CA, Jones IA. Long-term craniofacial osteoblast culture on a sodium phosphate and calcium/sodium phosphate glass. J Biomed Mater Res. 2003;66:233–240
  8. Hildebrand T, Laib A, Müller R, Dequeker J, Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calceneus. J Bone Miner Res. 1999;14:1167–1174
  9. Kurth AA, Müller R. The effect of an osteolytic tumor on the three-dimensional trabecular bone morphology in an animal model. Skeletal Radiol. 2001;30:94–98
  10. Müller R, Van Campenhout H, Van Damme B, et al. Morphometric analysis of human bone biopsies: a quantitative structural comparison of histological sections and micro-computed tomography. Bone. 1998;23:59–66
  11. Efeoglu C, Fisher SE, Ertϋrk S, Oztop F, Günbay S, Sipahi A. Quantitative morphometric evaluation of critical size experimental bone defects by microcomputed tomography. Br J Oral Maxillofac Surg. 2007;45:203–207
  12. Rüegsegger P, Koller B, Müller R. A microtomographic system for the non-destructive evaluation of bone architecture. Calcif Tiss Int. 1996;58:24–29
  13. Frame JW. A convenient animal model for testing bone substitute materials. J Oral Surg. 1980;38:176–180
  14. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Relat Res. 1986;205:299–308
  15. Zellin G, Beck S, Hardwick R, Linde A. Opposite effects of recombinant human transforming growth factor-beta 1 on bone regeneration in vivo: effects of exclusion of periosteal cells by microporous membrane. Bone. 1998;22:613–620
  16. Cacciafesta V, Dalstra M, Bosch C, Melsen B, Andreassen TT. Growth hormone treatment promotes guided bone regeneration in rat calvarial defects. Eur J Orthod. 2001;23:733–740
  17. Lutolf MP, Weber FE, Schmoekel HG, et al. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol. 2003;21:513–518
  18. Verna C, Dalstra M, Wikesjö UM, Trombelli L, Carles B. Healing patterns in calvarial bone defects following guided bone regeneration in rats. A micro-CT scan analysis. J Clin Periodontol. 2002;29:865–870
  19. Jones AC, Sakellariou A, Limaye A, et al. Investigation of microstructural features in regenerating bone using micro computed tomography. J Mater Sci Mater Med. 2004;15:529–532
  20. Gielkens PF, Schortinghuis J, de Jong JR, et al. A comparison of micro-CT, microradiography and histomorphometry in bone research. Arch Oral Biol. 2008;53:558–566
  21. Rai B, Ho KH, Lei Y, et al. Polycaprolactone-20% tricalcium phosphate scaffolds in combination with platelet-rich plasma for the treatment of critical-sized defects of the mandible: a pilot study. J Oral Maxillofac Surg. 2007;65:2195–2205
  22. Lu M, Rabie AB. Microarchitecture of rabbit mandibular defects grafted with intramembraneous or endochondral bone shown by micro-computed tomography. Br J Oral Maxillofac Surg. 2003;41:385–391
  23. Odgaard A, Gundersen HJ. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. 1993;14:173–182

PII: S0266-4356(09)00072-2

doi: 10.1016/j.bjoms.2009.02.010

British Journal of Oral and Maxillofacial Surgery
Volume 47, Issue 8 , Pages 616-621 , December 2009

Article Tools

* Image Usage & Resolution