British Journal of Oral and Maxillofacial Surgery
Volume 47, Issue 6 , Pages 466-469, September 2009

Relation between the concentration of zinc in maternal whole blood and the risk of an infant being born with an orofacial cleft

  • K.K. Hozyasz

      Affiliations

    • Department of Paediatrics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland
    • Corresponding Author InformationCorresponding author.
    • ,
  • M. Kaczmarczyk

      Affiliations

    • Faculty of Chemistry, Warsaw University, Warsaw, Poland
    • ,
  • J. Dudzik

      Affiliations

    • Department of Paediatrics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland
    • ,
  • E. Bulska

      Affiliations

    • Faculty of Chemistry, Warsaw University, Warsaw, Poland
    • ,
  • Z. Dudkiewicz

      Affiliations

    • Department of Paediatric Surgery, Institute of Mother and Child, Warsaw, Poland
    • ,
  • M. Szymanski

      Affiliations

    • Department of Paediatrics, Institute of Mother and Child, Kasprzaka 17a, 01-211 Warsaw, Poland

Accepted 8 June 2009. published online 08 July 2009.

Abstract 

We investigated the relation between concentrations of maternal zinc and copper and the risk of an infant being born with an orofacial cleft. We did a case–control study using 116 mothers of children with isolated cleft lip with or without cleft palate (cleft group), and 64 mothers of unaffected children (control group). Mothers with a whole blood zinc concentration of 47.1μmol/L or less had a risk 2.5 times higher of having a child with an orofacial cleft than those with a higher concentration (or level) (95% CI 1.03–6.23; p<0.05). A low zinc concentration combined with a high copper concentration was seen only in the cleft group. This evidence suggests an association between concentrations of maternal zinc and the risk of orofacial clefts in offspring.

Keywords: Cleft lip, Cleft palate, Zinc, Copper, Whole blood

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PII: S0266-4356(09)00216-2

doi:10.1016/j.bjoms.2009.06.005

British Journal of Oral and Maxillofacial Surgery
Volume 47, Issue 6 , Pages 466-469, September 2009

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