Expression and importance of inhibitor of DNA binding helix–loop–helix protein in salivary adenoid cystic carcinoma

Xie, WeiHong; Li, XinMing; GuoXin, Ren; Guo, Wei

doi:10.1016/j.bjoms.2009.08.008

« Previous Next »British Journal of Oral and Maxillofacial Surgery
Volume 48, Issue 6 , Pages 434-437, September 2010

Expression and importance of inhibitor of DNA binding helix–loop–helix protein in salivary adenoid cystic carcinoma

Xie WeiHong
- Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China
- Present address: Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Li XinMing
- Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, 450052, China
Ren GuoXin
- Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China
- Corresponding authors. Tel.: +86 021 63135129.
Guo Wei
- Shanghai Key Laboratory of Stomatology, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, School of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China
- Corresponding authors. Tel.: +86 021 63135129.

Accepted 11 August 2009. published online 22 September 2009.

Abstract

Studies have reported that Id-1 (inhibitor of DNA binding, or differentiation 1) protein, helix–loop–helix (HLH) transcription factor, has important roles in the development of several carcinomas. However, the role of Id-1 protein in salivary adenoid cystic carcinoma (ACC) is not clear. The expression of Id-1 protein was assessed in formalin-fixed, paraffin-embedded surgical specimens of ACCs by immunohistochemical staining. Thirty-nine of the 54 specimens of ACC stained for Id-1expression, which was significantly more than was found in pleomorphic adenomas (4/12) and normal salivary gland tissues (1/10, p<0.05). There were also significant differences between stages I and II (7/14) and III-IV (32/40) (p<0.05). Of tumours with metastases, 31/38 stained for Id-1, which was significantly higher than among those without metastases (8/16) (p<0.05). Our results showed that Id-1 may have important roles in the development of salivary ACC. It might also be a useful therapeutic tool to help prevent salivary ACC or to inhibit its malignant progression.