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Abstract
To study the efficacy of coumarin/troxerutine for the protection of salivary glands
and mucosa during irradiation. Design: Prospective, randomized, placebo-controlled,
double-blind trial. Setting: University hospital, Germany. Patients: 48 patients who
had radiotherapy to the head and neck. Main outcome measures: Salivary gland scintigraphy
and acute side-effects of radiotherapy (Radiation Therapy Oncology Group (RTOG) score).
Results: 23 patients (11 experimental, 12 placebo) completed the study. The global
efficacy measure combining scintigraphy and RTOG score favoured the experimental arm
(P= 0.07). The RTOG score showed significantly fewer acute side-effects of radiation
in the experimental arm (P< 0.05). Conclusion: The results suggest that coumarin/troxerutine have a favourable
effect in the treatment of radiogenic sialadenitis and mucositis.
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Article info
Publication history
Accepted:
May 14,
2000
Received:
September 23,
1999
Identification
Copyright
© 2001 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
