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Abstract
To investigate the contributions of various cytokines that are involved in mechanically
related bone formation, we applied defined uniaxial strains in a rabbit model of mandibular
elongation and examined the regenerating bone during early stages of dist raction
osteogenesis by histomorphometry. We also measured serum concentrations of various
cytokines during the distraction.
Cell proliferation and differentiation indices correlated significantly (P<0.001)
with the extent of load application. Serum concentrations of insulin-like growth factor-1
(IGF-1) decreased after osteotomy whereas transforming growth factor β1 (TGFβ1) showed
a postoperative increase. Prostaglandin E2 (PGE2) concentrations were constant throughout
the experimental period. Collagen degradation decreased slightly postoperatively and
increased in samples exposed to higher magnitudes of strain. Our data show that it
is the magnitude of mechanical strain that decides tissue response by a characteristic
cell proliferation and differentiation. The operative trauma leads to inverse changes
in serum concentrations of TGFβ1 and IGF-1, thereby promoting the recruitment of osteoblastic
precursor cells as well as collagen matrix synthesis.
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Article info
Publication history
Accepted:
September 7,
2000
Received:
November 21,
1999
Identification
Copyright
© 2001 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
