Abstract
The purpose of this study was to evaluate the effect of submucous tramadol as adjuvant
of mepivacaine with epinephrine in inferior alveolar nerve block. A double-blind,
randomized, placebo-controlled, crossover clinical trial was conducted. Twenty healthy
young volunteers were randomized into two treatment sequences using a series of random
numbers. Sequence 1: Group A, 2% mepivacaine with 1:100,000 epinephrine plus submucous
tramadol 50 mg (1 mL of saline) and one week later Group B, 2% mepivacaine with 1:100,000 epinephrine
plus submucous placebo (1 mL of saline). Sequence 2: Group B and one week later Group A. All treatments were
administered 1 min after that patient informed anesthesia of lower lip. We evaluated the duration
of anesthesia of lower lip, anesthetic efficacy, and local and systemic adverse events.
Anesthetic efficacy was better in group receiving submucous tramadol during the first
2 h compared with group receiving submucous placebo (P < 0.05). Submucous tramadol increased the anesthetic efficacy of mepivacaine with epinephrine
of soft tissue in inferior alveolar nerve block.
Keywords
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References
- An update on local anesthetics in dentistry.J Can Dent Assoc. 2002; 68: 546-551
- Comparative study of the anesthetic efficacy of 4% articaine versus 2% lidocaine in inferior alveolar nerve block during surgical extraction of impacted lower third molars.Med Oral Patol Oral Cir Bucal. 2007; 12: E139-E144
- A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanyl on dorsal root axons.Anesth Analg. 1996; 83: 776-781
- Tramadol added to mepivacaine prolonged the duration of an axillary brachial plexus blockade.Anesth Analg. 1999; 88: 853-856
- Tramadol added to 1.5% mepivacaine for axillary brachial plexus block improves postoperative analgesia dose-dependently.Anesth Analg. 2004; 98: 1172-1177
- The revised CONSORT statement for reporting randomized trials: explanation and elaboration.Ann Intern Med. 2001; 134: 663-694
- Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked potentials in rats.Anesth Analg. 2001; 92: 1547-1551
- Local anesthetic effect of tramadol, metoclopramide, and lidocaine following intradermal injection.Reg Anesth Pain Med. 1998; 23: 580-583
- The peripheral analgesic effect of tramadol in reducing propofol injection pain: a comparison with lidocaine.Reg Anesth Pain Med. 1999; 24: 246-249
- Comparison of local anaesthetic effects of tramadol with prilocaine for minor surgical procedures.Br J Anaesth. 2003; 90: 320-322
- The postoperative analgesic effect of tramadol when used as subcutaneous local anesthetic.Anesth Analg. 2004; 99: 1461-1464
- Modulation of the hyperpolarization-activated current (Ih) by cyclic nucleotides in guinea-pig primary afferent neurons.J Physiol. 1996; 492: 97-106
- Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors.Proc Natl Acad Sci USA. 1996; 93: 1108-1112
- Substance P release from knee joint afferent terminals: modulation by opioids.Brain Res. 1988; 458: 319-324
- An ATP-dependent K+ channel blocker antagonizes morphine analgesia.Eur J Pharmacol. 1990; 186: 377-378
- Effects of the central analgesic tramadol on the uptake and release of noradrenaline and dopamine in vitro.Br J Pharmacol. 1993; 108: 806-811
- Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus.Br J Anaesth. 1997; 79: 352-356
- Involvement of potassium channels and nitric oxide in tramadol antinociception.Pharmacol Biochem Behav. 2005; 80: 69-75
- Molecular mechanisms of local anesthesia: a review.Anesthesiology. 1990; 72: 711-734
- Tramadol added to mepivacaine prolongs the duration of an axillary brachial plexus blockade.Anesth Analg. 1999; 88: 853-856
- The effects of tramadol added to articaine on anesthesia duration.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102: 614-617
- Preoperative intravenous tramadol versus ketorolac for preventing postoperative pain after third molar surgery.Int J Oral Maxillofac Surg. 2004; 33: 274-278
- The analgesic efficacy of intravenous versus oral tramadol for preventing postoperative pain after third molar surgery.J Oral Maxillofac Surg. 2005; 63: 1162-1168
Article info
Publication history
Published online: May 10, 2011
Accepted:
February 28,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
