Abstract
The aim of this study was to evaluate the effectiveness of liposome-encapsulated ropivacaine
(0.5%) in dental anaesthesia. This randomised, double-blind, crossover, four-period
treatment study included 40 volunteers who were given 1.8 ml of the following local anaesthetics into the buccal sulcus at the right level of
the upper canine: 0.5% ropivacaine; 0.5% ropivacaine with 1:200,000 adrenaline; liposome-encapsulated
0.5% ropivacaine; and 2% lignocaine with 1:100,000 adrenaline. Onset of pulpal anaesthesia;
the success of anaesthesia; and the duration of labial, gingival, and pulpal anaesthesia
involving the upper right canine and first premolar were evaluated. At the end of
each injection, volunteers rated the pain on injection on a visual analogue scale
(VAS). Both ropivacaine and adrenaline, and lignocaine with adrenaline, were more
successful anaesthetic agents than liposome-encapsulated ropivacaine or plain ropivacaine
(p < 0.05). There were no significant differences among the anaesthetic preparations in
the onset of pulpal anaesthesia. Ropivacaine and adrenaline and lignocaine and adrenaline
gave a significantly longer duration of pulpal anaesthesia. VAS showed no significant
differences among the groups tested. The results showed that encapsulation of liposome
did not improve the anaesthetic efficacy of ropivacaine.
Keywords
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Article info
Publication history
Published online: August 10, 2011
Accepted:
July 14,
2011
Footnotes
☆Trial registration number of this study is NCT01307969.
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
