Research Article| Volume 50, ISSUE 5, P440-442, July 2012

Cytogenetics of jaw cysts – a pilot study

  • Esther Manor
    Institute of Human Genetics, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
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  • Peter A. Brennan
    Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
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  • Lipa Bodner
    Corresponding author at: Oral and Maxillofacial Surgery, Chair, Department of Oral and Maxillofacial Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, P.O. Box 151, Beer-Sheva 84101, Israel. Tel.: +972 8640 0505; fax: +972 8640 3651.
    Department of Oral and Maxillofacial Surgery, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84101, Israel
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Published:August 10, 2011DOI:


      The pathogenesis of cysts that arise in the jaws is still not certain, and the underlying mechanisms of epithelial proliferation are not fully understood. Cysts of the jaw may involve a reactive, inflammatory, or neoplastic process. Cytogenetics, the study of the number and structure of chromosomes, has provided valuable information about the diagnosis, prognosis, and targeted treatment in many cancers, including oral squamous cell carcinoma. Cytogenetics can also provide information about the possible aetiology or neoplastic potential of a lesion, though to our knowledge no studies of this technique have been used for cysts in the jaws. In this pilot study we used cytogenetics in a series of 10 cysts (3 radicular, 4 dentigerous, 2 of the nasopalatine duct, and 1 dermoid). In all cases we found normal karyotypes. Further work and larger numbers are needed for a definitive study, but we can hypothesise from this pilot study that these cysts do not have cytogenetic aberrations and so have no neoplastic potential.


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