Abstract
The pathogenesis of cysts that arise in the jaws is still not certain, and the underlying
mechanisms of epithelial proliferation are not fully understood. Cysts of the jaw
may involve a reactive, inflammatory, or neoplastic process. Cytogenetics, the study
of the number and structure of chromosomes, has provided valuable information about
the diagnosis, prognosis, and targeted treatment in many cancers, including oral squamous
cell carcinoma. Cytogenetics can also provide information about the possible aetiology
or neoplastic potential of a lesion, though to our knowledge no studies of this technique
have been used for cysts in the jaws. In this pilot study we used cytogenetics in
a series of 10 cysts (3 radicular, 4 dentigerous, 2 of the nasopalatine duct, and
1 dermoid). In all cases we found normal karyotypes. Further work and larger numbers
are needed for a definitive study, but we can hypothesise from this pilot study that
these cysts do not have cytogenetic aberrations and so have no neoplastic potential.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to British Journal of Oral and Maxillofacial SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Shear M. Speight P.M. Cysts of the oral and maxillofacial regions. 4th ed. Blackwell Munksgaard, Oxford2007
- Barnes L. Eveson J.W. Reichart P. Sidransky D. World Health Organization classification of tumors. Pathology and genetics of head and neck tumors. IARC Press, Lyon2005
- The aggressive nature of the odontogenic keratocyst is it a benign cystic neoplasm? Part 2: proliferation and genetic studies.Oral Oncol. 2002; 38: 323-331
- PTCH gene altered in dentigerous cysts.J Oral Pathol Med. 2001; 30: 569-576
- Actual proliferating index and p53 protein expression as prognostic marker in odontogenic cysts.Oral Dis. 2009; 15: 490-498
- Tumor angiogenesis in keratinocystic odontogenic tumor assessed by using CD-105 antigen.J Oral Pathol Med. 2011; 40: 263-269
- Odontogenic epithelium: immunolabeling of Ki-67, EGFR and survinin in pericoronal follicles, dentigerous cysts and keratocystic odontogenic tumors.Head Neck Pathol. 2011; 5: 1-7
- Cytogenetic and fluorescence in situ hybridization analysis of a basal cell adenocarcinoma of the mandible.Cancer Genet Cytogenet. 2006; 166: 186-188
- Chromosomal aberrations in oral solitary fibrous tumor.Cancer Genet Cytogenet. 2007; 174: 170-172
- Translocation (2;13) and other chromosome abnormalities in intraosseous schwannoma of the mandible.Cancer Genet Cytogenet. 2009; 193: 116-118
- Translocation (12;14) and other chromosome abnormalities in squamous cell carcinoma of the tongue.Euro Arch Otorhinolaryngol. 2010; 267: 1273-1276
- Cytogenetics-in color and digitized.N Engl J Med. 2004; 350: 1597-1600
- Cytogenetics of solid tumours.Methods Mol Biol. 2011; 730: 173-187
- Molecular cytogenetics in solid tumors: laboratorial tool for diagnosis, prognosis, and therapy.Oncologist. 2003; 8: 45-48
- Shaffer L.G. Slovak M.L. Campbell L.J. ISCN 2009: an international system for human cytogenetic nomenclature. S. Karger, Basel2009
- Location of gene for Gorlin syndrome.Lancet. 1992; 339: 581-582
- p53 expression in odontogenic keratocyst epithelium.J Oral Pathol Med. 1996; 25: 249-255
- Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome.Hum Genet. 1997; 100: 497-502
- Mutation and cancer: statistical study of retinoblastoma.Proc Natl Acad Sci USA. 1971; 68: 820-823
- The odontogenic keratocyst: a cyst, or a cystic neoplasm?.J Dent Res. 2011; 90: 133-142
- Biological pathways involved in the aggressive behavior of the keratinocystic odontogenic tumor and possible implication for molecular oriented treatment-an overview.Oral Oncol. 2010; 46: 19-24
Article info
Publication history
Published online: August 10, 2011
Accepted:
July 19,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
