Abstract
In our previous studies, prototyped individual bone-grafting trays have been used
to restore discontinuous mandibular defects. However, the attempts have shown that
the trays have shielded the graft from stress, which caused considerable resorption
of bone. To eliminate the shielding, we designed a flexible tray. Finite element analysis
was used to compare the distribution of strain on the bone grafts that were placed
in flexible and conventional trays. The analogue computation suggested that most of
the strain on the graft in the flexible tray resulted in a beneficial mechanical environment,
while in the conventional tray more than half of graft was in the lowest class of
strain (disuse – <50 μstrains). Animal experiments were conducted on hybrid dogs, and the prototype flexible
tray was used to carry particles of autologous cancellous iliac bone to reconstruct
a 40 mm defect in the mandibular body. Sequential radionuclide bone imaging was used to
monitor the bone metabolism. Animals were killed at 4, 12 and 24 weeks, and specimens
processed for quantitative histological examination. The data from the flexible trays
were compared with those from the conventional trays, as in our previous study. The
results showed that bone metabolism was more active in the flexible tray than in the
conventional tray during the early stages. There was increased bony adaptation in
the flexible tray. These results indicate that the flexible tray can efficiently eliminate
the shielding from stress, and allow more occlusive force to be conducted on to the
bone graft, which results in better remodelling of the graft.
Keywords
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Article info
Publication history
Published online: October 05, 2011
Accepted:
August 8,
2011
Identification
Copyright
© 2011 Published by Elsevier Inc.
