Abstract
Patients with chronic myeloid leukaemia (CML) are at considerable risk of developing
second primary neoplasms. However, mucosal squamous cell cancers (SCCs) of the head
and neck have not been reported. We review the data of 7 patients with mucosal SCC
of the head and neck that presented as metachronous second primary tumours in patients
with CML. All 7 patients were men (median age 48 years, range 31–67) (site:oral cavity
n = 6, hypopharynx n = 1). The median interval between diagnosis of CML and head neck cancer was 6 years
(range 2–15). Treatment was curative in 4 and palliative in 3. At median follow up
of 14 months (range 2–44), 3 patients had died of head and neck cancer, 1 of CML,
and 3 were alive and free of disease. Mucosal cancers of the head and neck can occur
in long-term survivors of CML. They are aggressive and tend to recur.
Keywords
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Article info
Publication history
Published online: November 28, 2011
Accepted:
August 16,
2011
Identification
Copyright
© 2011 Published by Elsevier Inc.
