Abstract
Oral verrucous carcinoma (OVC) is a low-grade variant of squamous cell carcinoma (SCC)
with a distinctive morphology and specific pattern of behaviour that is often diagnosed
in elderly patients. Resection is the treatment of choice, with radiotherapy as a
reasonable alternative. In this retrospective case review we present our experience
and outcomes in a group of 12 patients with various stages of OVC who had not been
treated conventionally because of the extent of their lesions and their poor general
condition. All patients were given chemotherapy with methotrexate, which was given
by various routes and in different doses during the period 1972–2010. In 11 patients
treatment with methotrexate alone was beneficial. One patient failed to respond. Methotrexate
used alone as chemotherapy may minimise morbidity and improve quality of life, particularly
among elderly patients.
Keywords
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Article info
Publication history
Published online: October 17, 2011
Accepted:
September 15,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
