Abstract
We have evaluated transplantation of reduced submandibular glands for the treatment
of severe keratoconjunctivitis sicca. Thirty-four rabbits were allocated into three
groups: dry eye (controls, n = 10), transplantation of whole submandibular glands (n = 12), and transplantation of reduced submandibular glands (n = 12). Outcome measures included the results of Schirmer's test and the Rose Bengal
test, and histological examination of the cornea and the transplanted gland. Volume
of tears significantly increased after transplantation of the whole gland, but did
not change after transplantation of the reduced gland compared with dry eyes induced
preoperatively. Neither transplantion group had keratoconjunctivitis sicca postoperatively.
There were no histological abnormalities in the transplanted tissues. The results
that the surgical technique of using reduced submandibular glands for transplantation
was feasible, and that the secretion from the reduced gland was similar to that from
a normal lacrimal gland. In conclusion, transplantation of a reduced submandibular
glands is feasible in the treatment of keratoconjunctivitis sicca.
Keywords
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References
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Article info
Publication history
Published online: November 03, 2011
Accepted:
October 13,
2011
Identification
Copyright
© 2011 Published by Elsevier Inc.
