Abstract
To record the demographics, and correlate histological findings in central giant cell
granulomas (CGCGs) of the jaws with their clinical behaviour, 30 paraffin-embedded
samples of CGCG were retrieved from the archives of the Department of Oral Pathology
and Microbiology, Subharti Dental College, Meerut, India. The diagnosis in each case
was made on the basis of clinical, radiographic, and histological findings. Data about
age, sex, anatomical site, presentation, radiological features, and laboratory investigations
were analysed. Histomorphometric analyses were made in each case with respect to the
number of giant cells, mean number of nuclei and giant cells, fractional surface area
occupied by giant cells, index of relative size, and mitotic activity. The peak incidence
of CGCG was during the second decade of life with a slight female predilection, and
the mandible was the most common site. Of the 30 samples considered, 20 tumours were
classified clinically as non-aggressive, and 10 as aggressive, based on their clinical
behaviour. Histomorphometric analysis showed significant changes between the two groups
with respect to the number of giant cells, the fractional surface area, and the mitotic
activity. The data obtained showed clinical and histomorphometric features that may
be reliable indicators for the differentiation between aggressive and non-aggressive
CGCG. These data should be taken into consideration to improve planning of individual
treatment and follow-up.
Keywords
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Article info
Publication history
Published online: December 26, 2011
Accepted:
October 31,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
