Abstract
Our aim was to evaluate the effects of hydrofluoric acid and anodised micro and micro/nano
surface implants on bony ingrowth in the earliest stage of implantation in rats. Sixty
cylindrical screwed titanium alloy implants with machined, micro, and hierarchical
hybrid micro/nano surfaces (n = 20 in each group) were inserted into the distal femurs of 30 female Sprague-Dawley
rats. In vivo microcomputed tomography (micro CT) was used to assess microarchitectural
changes in the bone around the implants 2 weeks after implantation. All the animals
were then killed and the femurs with implants harvested for histological analysis
and pull-out testing. Micro CT analysis showed that the trabecular thickness and the
bone:volume ratio (bone volume:total volume) (BV:TV) increased significantly in the
micro/nano group compared with the other two groups, while the trabecular separation
decreased significantly in the micro/nano group compared with the machined group.
The mean (SD) bone-implant contacts (%) were 38.94 (9.48), 41.67 (8.71), and 51.49
(12.49) in the machined, micro, and micro/nano groups, respectively. The maximum pull-out
forces (N) were 64.95 (6.11), 71.45 (7.15), and 81.90 (13.1), respectively. Both bone-implant
contacts and maximum pull-out forces were significantly higher in the micro/nano group,
but there was no significant difference between the micro group and the machined group.
These data indicate that the hierarchical hybrid micro/nano surface of the implant
can promote osseointegration in the earliest stage of implantation, and may be a promising
option for further clinical use.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to British Journal of Oral and Maxillofacial SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Rapid implant therapies: immediate implant placement and immediate restoration.J Dent Sci. 2009; 4: 1-6
- Introduction to osseointegration.in: Branemark P.I. Zarb G.A. Albrektsson T. Tissue-integration prostheses. Osseointegration in clinical dentistry. Quintessence, Chicago1985
- The role of primary stability for successful immediate loading of dental implants. A literature review.J Dent. 2010; 38: 612-620
- The acceleration of implant osseointegration by liposomal Wnt3a.Biomaterials. 2010; 31: 9173-9181
- Effects of surface roughness of titanium implants on bone remodeling activity of femur in rabbits.Bone. 1997; 21: 507-514
- Implant surface roughness and bone healing: a systematic review.J Dent Res. 2006; 85: 496-500
- The relation between surface roughness and interfacial shear strength for bone-anchored implants. A mathematical model.J Biomech. 1999; 32: 829-836
- Surface characteristics and structure of anodic oxide films containing Ca and P on a titanium implant material.J Biomed Mater Res. 2002; 60: 333-338
- Nanomedicine for implants: a review of studies and necessary experimental tools.Biomaterials. 2006; 28: 354-369
- The influence of hierarchical hybrid micro/nano-textured titanium surface with titania nanotubes on osteoblast functions.Biomaterials. 2010; 31: 5072-5082
- The effect of hierarchical micro/nanosurface titanium implant on osseointegration in ovariectomized sheep.Osteoporos Int. 2011; 22: 1907-1913
- Mechanical properties and the hierarchical structure of bone.Med Eng Phys. 1998; 20: 92-102
- Advancing dental implant surface technology—from micron- to nanotopography.Biomaterials. 2008; 29: 3822-3835
- Early bone response to sandblasted, dual acid-etched and H2O2/HCl treated titanium implants: an experimental study in the rabbit.Int J Oral Maxillofac Surg. 2009; 38: 677-681
- Greater in vivo bone growth on anodized nanotubular titanium.Ortho Res Soc Proc. 2009; : 1887
- Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies.Eur Cell Mater. 2003; 6: 22-27
- The interaction of cells and bacteria with surfaces structured at the nanometre scale.Acta Biomater. 2010; 6: 3824-3846
- Cellular behavior on TiO2 nanonodular structures in a micro-to-nanoscale hierarchy model.Biomaterials. 2009; 30: 5319-5329
- Surface treatments of titanium dental implants for rapid osseointegration.Dent Mater. 2007; 23: 844-854
- Improved retention and bone-tolmplant contact with fluoride-modified titanium implants.Int J Oral Maxillofac Implants. 2004; 19: 659-666
Article info
Publication history
Published online: January 18, 2012
Accepted:
December 19,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
