Abstract
Injections into the palate are common in dental treatment and are unpleasant for the
patient. A liposomal encapsulation technique was developed to improve the efficacy
of 2% lignocaine dental injection so that it could be used as a topical anaesthetic.
Liposome-encapsulated 2% lignocaine was prepared as needed by sonicating 2% lignocaine
hydrochloride dental injection (with 1:100,000 adrenaline) with a lipid mixture using
a dental ultrasonic scaler for 1 min. The time to onset and time to take effect were calculated by a pinprick test
in the palatal mucosa in 10 normal subjects. In another experiment, the preparation
was tested in a further 22 subjects for its pain-relieving effect during a standard
palatal injection, and compared with 18% benzocaine/2% tetracaine gel. The results
showed that the mean (SD) time to onset and time to take effect of the liposome-encapsulated
2% lignocaine were 39.0 (21.4) and 157.5 (2.3) s, respectively, and the mean (SD) pain score measured on a visual analogue scale
(VAS) during injection was 4.1 (2.3) cm. After the application of the gel the corresponding measurement was 4.8 (2.8) cm (p = 0.045). The encapsulation of 2% lignocaine dental injection in liposomes by a dental
ultrasonic scaler was effective in improving the efficacy of the anaesthetic for topical
application.
Keywords
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Article info
Publication history
Published online: January 25, 2012
Accepted:
December 21,
2011
Identification
Copyright
© 2011 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
