Advertisement

Synchronous metastatic adenoid cystic and squamous cell carcinoma of the cervical lymph nodes 31 years after ablation of the primary palatal tumour

Published:August 06, 2012DOI:https://doi.org/10.1016/j.bjoms.2012.07.010

      Abstract

      The coexistence of different types of malignancy in cervical lymph nodes has been reported previously. We report the first case, to the best of our knowledge, of concurrent metastatic adenoid cystic carcinoma and squamous cell carcinoma (SCC) in cervical lymph nodes. A primary SCC developed three decades after treatment for adenoid cystic carcinoma of the palate, and the synchronous metastases became clinically apparent the following year. The aetiology of the SCC may have been related to radiotherapy or smoking. Whether the adenoid cystic carcinoma would have remained dormant, or was reactivated after perturbation of host defence mechanisms, is not known.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to British Journal of Oral and Maxillofacial Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Barrett A.W.
        • Speight P.M.
        Perineural invasion in adenoid cystic carcinoma of the salivary glands: a valid prognostic indicator?.
        Oral Oncol. 2009; 45: 936-940
        • Barrett A.W.
        • Speight P.M.
        Perineural invasion in adenoid cystic carcinoma of the salivary glands: anatomical influences on oncological management.
        Current Cancer Therapy Reviews. 2011; 7: 78-82
        • Eveson J.W.
        • Nagao T.
        Diseases of salivary glands.
        in: Barnes L. Surgical pathology of the head and neck. 3rd ed. Informa Healthcare USA, New York2009: 475-647
        • Mburu Y.K.
        • Ferris R.L.
        Chemokines and their receptors in oral cancer metastasis.
        in: Myers J. Oral cancer metastasis. 1st ed. Springer, New York2010: 287-298
        • Wang X.
        • Zhao J.
        • Fang X.
        • Xu N.
        • Zhang X.
        Adenoid cystic carcinoma, low-differentiation carcinoma, squamous cell carcinoma: a rare evolution of a tracheal malignancy within 27 years.
        J Clin Oncol. 2011; 29: e509-e511
        • El-Naggar A.K.
        • Huvos A.G.
        Adenoid cystic carcinoma.
        in: Barnes L. Eveson J.W. Reichart P. Sidransky D. World Health Organization classification of tumors: pathology and genetics: head and neck tumors. IARC Press, Lyon2005
        • Seethala R.R.
        • Hunt J.L.
        • Baloch Z.W.
        • Livolsi V.A.
        • Leon Barnes E.
        Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature.
        Am J Surg Pathol. 2007; 31: 1683-1694