Abstract
Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects
progression, invasion, and metastasis. However, to our knowledge, in East Asia, the
correlation between the expression of HSP90 and clinicopathological variables has
seldom been discussed. We therefore investigated this and its prognostic value in
36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan.
Samples of tumour and normal samples from the patients were compared immunohistochemically.
HSP90 was expressed mainly in the samples of tumour, and was significantly higher
in these than in the normal epithelium (p < 0.001). Metastases to the lymph nodes in the 36 patients also correlated with expression
of HSP90. Correlation between expression of HSP90 and the size of the tumour or pathological
staging was not significant, but strong expression correlated with poor survival.
In general, expression was low among our samples (30/36). It was significantly higher
in the tumour samples than in normal samples, and correlated with metastases to lymph
nodes in the neck.
Keywords
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Article Info
Publication History
Published online: February 13, 2017
Accepted:
January 15,
2017
Identification
Copyright
© 2017 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons.
