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Expression pattern of heat shock protein 90 in patients with oral squamous cell carcinoma in northern Taiwan

  • W.-C. Chang
    Affiliations
    Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
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  • P.-T. Tsai
    Affiliations
    Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
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  • C.-K. Lin
    Affiliations
    Department of Pathology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan, Republic of China

    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
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  • Y.-S. Shieh
    Affiliations
    Department of Operative Dentistry and Endodontology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
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  • Y.-W. Chen
    Correspondence
    Corresponding author at: Division of Oral and Maxillofacial Surgery of Tri-Service General Hospital, 2F, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei 114, Taiwan, Republic of China. Tel.: +886 2 87923311 ext. 88031; Mobile No.: +886 910900820; Fax: +886 2 87927147.
    Affiliations
    Department of Oral and Maxillofacial Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China

    School of Dentistry, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Search for articles by this author
Published:February 13, 2017DOI:https://doi.org/10.1016/j.bjoms.2017.01.008

      Abstract

      Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects progression, invasion, and metastasis. However, to our knowledge, in East Asia, the correlation between the expression of HSP90 and clinicopathological variables has seldom been discussed. We therefore investigated this and its prognostic value in 36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan. Samples of tumour and normal samples from the patients were compared immunohistochemically. HSP90 was expressed mainly in the samples of tumour, and was significantly higher in these than in the normal epithelium (p < 0.001). Metastases to the lymph nodes in the 36 patients also correlated with expression of HSP90. Correlation between expression of HSP90 and the size of the tumour or pathological staging was not significant, but strong expression correlated with poor survival. In general, expression was low among our samples (30/36). It was significantly higher in the tumour samples than in normal samples, and correlated with metastases to lymph nodes in the neck.

      Keywords

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