Abstract
Heat shock protein 90 (HSP90), which is expressed in cancer cells, profoundly affects
progression, invasion, and metastasis. However, to our knowledge, in East Asia, the
correlation between the expression of HSP90 and clinicopathological variables has
seldom been discussed. We therefore investigated this and its prognostic value in
36 patients newly diagnosed with oral squamous cell carcinoma (SCC) in northern Taiwan.
Samples of tumour and normal samples from the patients were compared immunohistochemically.
HSP90 was expressed mainly in the samples of tumour, and was significantly higher
in these than in the normal epithelium (p < 0.001). Metastases to the lymph nodes in the 36 patients also correlated with expression
of HSP90. Correlation between expression of HSP90 and the size of the tumour or pathological
staging was not significant, but strong expression correlated with poor survival.
In general, expression was low among our samples (30/36). It was significantly higher
in the tumour samples than in normal samples, and correlated with metastases to lymph
nodes in the neck.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to British Journal of Oral and Maxillofacial SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival.J Oral Maxillofac Surg. 2003; 61: 751-758
- Nonsquamous cell malignant tumours of the oral cavity: an overview.J Can Dent Assoc. 2003; 69: 577-582
- Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma.Int J Oral Maxillofac Surg. 2007; 36: 671-679
- Cancer statistics, 2009.CA Cancer J Clin. 2009; 59: 225-249
- Histopathological prognosticators in oral and oropharyngeal squamous cell carcinoma.Oral Oncol. 2006; 42: 229-239
- Recent advances in head and neck cancer.N Engl J Med. 2008; 359: 1143-1154
- Hsp70 and Hsp90—a relay team for protein folding.Rev Physiol Biochem Pharmacol. 2004; 151: 1-44
- Hallmarks of cancer: the next generation.Cell. 2011; 144: 646-674
- Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.J Biol Chem. 2002; 277: 39858-39866
- Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma.Cancer Res. 2002; 62: 7350-7356
- A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies.BMC Cancer. 2013; 13: 152
- Targeting the dynamic HSP90 complex in cancer.Nat Rev Cancer. 2010; 10: 537-549
- Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.Biochim Biophys Acta. 2012; 1823: 742-755
- Biomarkers distinguishing mammary fibroepithelial neoplasms: a tissue microarray study.Appl Immunohistochem Mol Morphol. 2014; 22: 433-441
- Targeting the molecular chaperone heat shock protein 90 (HSP90): lessons learned and future directions.Cancer Treat Rev. 2013; 39: 375-387
- A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.Nature. 2003; 425: 407-410
- Molecular chaperones and the stress of oncogenesis.Oncogene. 2004; 23: 2907-2918
- Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.Cell Stress Chaperones. 2005; 10: 86-103
- Heat shock protein and p53 expression in head and neck squamous cell carcinoma.Otolaryngol Head Neck Surg. 1998; 118: 610-615
- Hsp90 and co-chaperones twist the functions of diverse client proteins.Biopolymers. 2010; 93: 211-217
- Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma.Anticancer Res. 2011; 31: 1197-1204
- Heat shock protein 90 (HSP90) is overexpressed in p16-negative oropharyngeal squamous cell carcinoma, and its inhibition in vitro potentiates the effects of chemoradiation.Cancer Chemother Pharmacol. 2014; 74: 1015-1022
- Decreased GRP78 protein expression is a potential prognostic marker of oral squamous cell carcinoma in Taiwan.J Formos Med Assoc. 2010; 109: 326-337
Article info
Publication history
Published online: February 13, 2017
Accepted:
January 15,
2017
Identification
Copyright
© 2017 Published by Elsevier Ltd on behalf of The British Association of Oral and Maxillofacial Surgeons.
