Adjuvant or primary radiotherapy may form part of the management of head and neck cancer. The benefits have been well documented, but there is no doubt that craniofacial osteoradionecrosis is a late complication of this type of treatment, and can be fatal.
- De Felice F.
- Musio D.
- Tombolini V.
Osteoradionecrosis and intensity modulated radiation therapy: an overview.
Crit Rev Oncol Hematol. 2016; 107: 39-43
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- Osteoradionecrosis and intensity modulated radiation therapy: an overview.Crit Rev Oncol Hematol. 2016; 107: 39-43
- Classification of craniofacial osteoradionecrosis: the addition of “end stage disease”.Br J Oral Maxillofac Surg. 2018; 56: 897-898
- HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomized controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible after dentoalveolar surgery.Int J Radiat Oncol Biol Phys. 2019; 104: 530-539
- Complete restoration of refractory mandibular osteoradionecrosis by prolonged treatment with a pentoxifylline-tocopherol-clodronate combination (PENTOCLO): a phase II trial.Int J Radiat Oncol Biol Phys. 2011; 80: 832-839
Published online: November 22, 2019
© 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.