Abstract
The albumin:globulin (A:G) ratio, adult comorbidity evaluation 27 (ACE-27), and TMN
staging have been shown to be strong predictive indicators of the survival of patients
with many types of tumours. We have investigated the prognostic value of pretreatment
based on the A:G ratio combined with TMN staging and ACE-27 in patients with squamous
cell carcinoma (SCC) of the maxillary sinus. We studied 196 patients, and the prognostic
value was explored by univariate and multivariate Cox’s hazards analysis. Multivariate
analyses suggested that pretreatment A:G ratio was independently associated with overall
survival (hazard ratio (HR) 1.542, 95% CI 1.219 to 1.991, p = 0.002); disease-specific survival, (HR 1.499, 95% CI 1.197 to 1.842, p = 0.001); and disease-free survival (HR 1.452, 95% CI 1.207 to 1.834, p < 0.001). Additional prognostic factors shown in the survival analyses included ACE-27,
pathological T stage, and pathological N stage. Pretreatment A:G ratio combined with
ACE-27 and TMN staging were powerful prognostic indicators of outcome in patients
with SCC of the maxillary sinus, which has potentially important ramifications for
stratification of the disease in the future.
Keywords
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Article info
Publication history
Published online: November 25, 2019
Accepted:
November 8,
2019
Identification
Copyright
© 2019 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
