Advertisement
Research Article| Volume 58, ISSUE 3, P319-323, April 2020

Maxillomandibular advancement for the treatment of obstructive sleep apnoea syndrome: a long-term follow-up

  • M. Romano
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Maxillo-Facial and Dental Unit, Fondazione Ca’Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy
    Search for articles by this author
  • L. Karanxha
    Correspondence
    Corresponding author at: Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano Via Francesco Sforza 35, Milan, Italy. Tel.: +39 338 398 4882.
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Maxillo-Facial and Dental Unit, Fondazione Ca’Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy
    Search for articles by this author
  • A. Baj
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Maxillo-Facial and Dental Unit, Fondazione Ca’Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy
    Search for articles by this author
  • A.B. Giannì
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Maxillo-Facial and Dental Unit, Fondazione Ca’Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy
    Search for articles by this author
  • S. Taschieri
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy

    IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Search for articles by this author
  • M. Del Fabbro
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy

    IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Search for articles by this author
  • D. Rossi
    Affiliations
    Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Maxillo-Facial and Dental Unit, Fondazione Ca’Granda IRCCS Ospedale Maggiore Policlinico Milan, Italy
    Search for articles by this author
Published:February 27, 2020DOI:https://doi.org/10.1016/j.bjoms.2019.12.011

      Abstract

      Obstructive sleep apnoea syndrome (OSAS), which is characterised by repetitive episodes of pharyngeal collapse during sleep, is gaining much attention because of the important deleterious consequences it might have on the patient’s health. We therefore organised a retrospective longitudinal study to report the long-term follow-up of maxillomandibular advancement (MMA) as a treatment for OSAS. A total of 19 patients with severe OSAS was treated during the period 2007–2016. They were followed up six months postoperatively (T1) and after a mean follow up of 6.7 (range 4-10) years (T2, between November 2017 and February 2018) for the polysomnography variables, and the Epworth sleeping scale (ESS) and body mass index (BMI) were recorded. All polysomnographic variables improved significantly from baseline to T1 and from baseline to T2. The ESS significantly improved from baseline to T2. Nearly all patients at T1 and over two-thirds at T2 had a 50% reduction of the apnoea/hypopnoea index when compared with baseline, and a value lower than 20 of the same index. The BMI did not change significantly from T0 to T2. Our long-term follow-up has documented the stability of the outcomes of the MMA for the treatment OSAS.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to British Journal of Oral and Maxillofacial Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Guilleminault C.
        • Tilkian A.
        • Dement W.C.
        The sleep apnea syndromes.
        Annu Rev Med. 1976; 27: 465-484
        • Nieto F.J.
        • Young T.B.
        • Lind B.K.
        • et al.
        Association of sleep-disordered breating sleep apnea, and hypertension in a large community-based study. Sleep Heart Healt Study.
        JAMA. 2000; 283: 1989-2036
        • Yaggi H.K.
        • Concato J.
        • Kernan W.N.
        • et al.
        Obstructive sleep apnea as a risk factor for stroke and death.
        N Engl J Med. 2005; 353: 2034-2041
        • Kato M.
        • Adachi T.
        • Koshino Y.
        • et al.
        Obstructive sleep apnea and cardiovascular disease.
        Circ J. 2009; 73: 1363-1370
        • Sullivan C.E.
        • Berthon-Jones M.
        • Issa F.G.
        Nocturnal nasal-airway pressure for sleep apnea.
        N Engl J Med. 1983; 309: 112
        • McArdle N.
        • Devereux G.
        • Heidarnejad H.
        • et al.
        Long-term use of CPAP therapy for sleep apnea/hypopnea syndrome.
        Am J Respir Crit Care Med. 1999; 159: 1108-1114
        • Chan A.S.
        • Sutherland K.
        • Schwab R.J.
        • et al.
        The effect of mandibular advancement on upper airway structure in obstructive sleep apnoea.
        Thorax. 2010; 65: 726-732
        • Ngiam J.
        • Balasubramaniam R.
        • Darendeliler M.A.
        • et al.
        Clinical guidelines for oral appliance therapy in the treatment of snoring and obstructive sleep apnoea.
        Aust Dent J. 2013; 58: 408-419
        • Cowan D.C.
        • Livingston E.
        Obstructive sleep apnoea syndrome and weight loss: review.
        Sleep Disord. 2012; 2012163296
        • Tingting X.
        • Danming Y.
        • Xin C.
        Non-surgical treatment of obstructive sleep apnea syndrome.
        Eur Arch Otorhinolaryngol. 2018; 275: 335-346
        • Randerath W.J.
        • Verbraecken J.
        • Andreas S.
        • et al.
        Non-CPAP therapies in obstructive sleep apnoea. European Respiratory Society task force on non-CPAP therapies in sleep apnoea.
        Eur Respir J. 2011; 37: 1000-1028
        • Sundaram S.
        • Lim J.
        • Lasserson T.J.
        Surgery for obstructive sleep apnoea in adults.
        Cochrane Database Syst Rev. 2008; (No: CD001004)
        • Sher A.E.
        • Schechtman K.B.
        • Piccirillo J.F.
        The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome.
        Sleep. 1996; 19: 156-177
        • Caples S.M.
        • Rowley J.A.
        • Prinsell J.R.
        • et al.
        Surgical modifications of the uper airway for obstructive sleep apnea in adults: a systematic review and meta-analysis.
        Sleep. 2010; 33: 1396-1407
        • Spicuzza L.
        • Caruso D.
        • Di Maria G.
        Obstructive sleep apnea syndrome and its management.
        Ther Adv Chronic Dis. 2015; 6: 273-285
        • Berry R.B.
        • Budhiraja R.
        • Gottlieb D.J.
        • et al.
        American Academy of Sleep Medicine. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine.
        J Clin Sleep Med. 2012; 8: 597-619
        • Johns M.W.
        A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
        Sleep. 1991; 14: 540-545
        • Powell N.
        • Guilleminault C.
        • Riley R.X.
        • et al.
        Mandibular advancement and obstructive sleep apnea syndrome.
        Bull Eur Physiopathol Respir. 1983; 19 (697-10)
        • Krekmanov L.
        • Andersson L.
        • Rinqvist M.
        • et al.
        Anterior-inferior mandibular osteotomy in treatment of obstructive sleep apnea syndrome.
        Int J Adult Orthod Othognath Surg. 1998; 13: 289-297
        • Prinsell J.R.
        Primary and secondary telegnathic maxillomandibular advancement, with or without adjunctive procedures, for obstructive sleep apnea in adults: a literature review and treatment recommendations.
        J Oral Maxillofac Surg. 2012; 70: 1659-1677
        • Riley R.W.
        • Powell N.
        • Guilleminault C.
        Current surgical concepts for treating obstructive sleep apnea syndrome.
        J Oral Maxillofac Surg. 1987; 45: 149-157
        • Raunio A.
        • Rauhala E.
        • Kiviharju M.
        • et al.
        Bimaxillary advancement as the initial treatment of obstructive sleep apnea: five years follow-up of the pori experience.
        J Oral Maxillofac Res. 2012; 3: e5
        • Ronchi P.
        • Novelli G.
        • Colombo L.
        • et al.
        Effectiveness of maxillo-mandibular advancement in obstructive sleep apnea patients with and without skeletal anomalies.
        Int J Oral Maxillofac Surg. 2010; 39: 541-547
        • Vigneron A.
        • Tamisier R.
        • Orset E.
        • et al.
        Maxillomandibular advancement for obstructive sleep apnea syndrome treatment: long-term results.
        J Craniomaxillofac Surg. 2017; 45: 183-191
        • Conradt R.
        • Hochban W.
        • Brandenburg U.
        • et al.
        Long-term follow-up after surgical treatment of obstructive sleep apnoea by maxillomandibular advancement.
        Eur Respir J. 1997; 10: 123-128
        • Dekeister C.
        • Lacassagne L.
        • Tiberge M.
        • et al.
        Mandibular advancement surgery in patients with severe obstructive sleep apnea uncontrolled by continuous positive airway pressure. A retrospective review of 25 patients between 1998 and 2004.
        Rev Mal Respir. 2006; 23 (in French): 430-437
        • Boyd S.B.
        • Walters A.S.
        • Waite P.
        • et al.
        Long-term effectiveness and safety of maxillomandibular advancement for treatment of obstructive sleep apnea.
        J Clin Sleep Med. 2015; 11: 699-708