Abstract
The use of cold atmospheric pressure plasma (CAPP) as a bacterial decontaminant for
chronic wounds has shown good results. The purpose of this in vitro study was to evaluate
the bactericidal effects of CAPP on the cancellous area of the bone. Sterile glass
slides and processed sterile human bone allografts 1, 2, 3, and 4 mm thick were used for initial contamination and further CAPP treatment. Each block
was contaminated with Staphylococcus aureus suspension on one side. Each slide was turned 180° and treated on the reverse side.
The bacterial count in colony-forming units (CFU) was then measured and compared with
that of a control group, and the bactericidal effects of CAPP in relation to bone
density evaluated. A significant reduction in count was measured between treated and
untreated groups (groups A-D: p < 0.01 and group E: p = 0.04). A strong positive linear relation was found between bone density and the S aureus count (r = 0.844, p = 0.156). Treatment with CAPP had a bactericidal effect on bone structures with a penetration
depth of up to 4 mm. It might be used for all diseases involving infected bone, and so extends the
existing range of treatments.
Keywords
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Article info
Publication history
Published online: January 19, 2020
Accepted:
January 3,
2020
Identification
Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
