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Research Article| Volume 58, ISSUE 3, P334-340, April 2020

Evaluation of the efficacy of postoperative antibiotic treatment in transoral endoscopic thyroidectomy: a prospective randomised controlled trial

  • J.W. Yi
    Correspondence
    Corresponding author at: Inha University Hospital, 27, Inhang-ro, Jung-gu, Incheon, Republic of Korea. Tel: +82-32-890-2738; Fax: +82-32-890-3049.
    Affiliations
    Department of Surgery, Inha University Hospital, Incheon, Republic of Korea

    Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
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  • S.-j. Kim
    Affiliations
    Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
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  • K.E. Lee
    Affiliations
    Department of Surgery, Seoul National University Hospital, Seoul, Republic of Korea
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Published:January 22, 2020DOI:https://doi.org/10.1016/j.bjoms.2020.01.004

      Abstract

      Transoral endoscopic thyroid surgery (TOET) is a new, minimally-invasive approach that does not result in a scar in the anterior neck. To prevent infection of the surgical site from oral cavity flora into the thyroidectomy area, postoperative antibiotics are generally given orally for 3–7 days. However, there is no clinical evidence to support this approach. This study was an open-label, randomised, controlled trial to evaluate the clinical usefulness of postoperative antibiotics given orally to patients having TOET. Patients were randomly assigned to receive amoxicillin-clavulanate 625 mg orally three times a day for a week after operation (treated group) or no antibiotics (untreated group). Fifty patients – 25 treated and 25 untreated – were enrolled. Maximum body temperature, pulse rate, white blood cell count, and C-reactive protein concentrations did not differ between the two groups. Evaluation of the surgical site showed no significant differences between them. Seven patients in the treated group developed nausea, vomiting, and diarrhoea compared with none in the untreated group. The results suggest that postoperative oral antibiotics are not essential after TOET. Large-scale prospective series are required to confirm this finding.

      Keywords

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