We read with great interest the recent paper by Cavalcante et al, “Association between
facial measurements and polymorphisms in human epidermal growth factor and transforming
growth factor β1”.
1
They noted that “Genetic polymorphisms in EGF and TGF-β1 are associated with facial measurements in
a Brazilian population of patients with dentofacial deformities.”
- Cavalcante R.C.
- Bergamaschi I.P.
- Sebastiani A.M.
- et al.
Association between facial measurements and polymorphisms in human epidermal growth
factor and transforming growth factor β1.
Br J Oral Maxillofac Surg. 2020; (pii: S0266-4356(19)30781-8. [Epub ahead of print])https://doi.org/10.1016/j.bjoms.2019.11.024
1
In fact, the molecular change attributed to EGF and TGF-β1 can result in altered phenotypic expression. Nevertheless, there are also other genetic
polymorphisms that are associated with facial measurements
- Cavalcante R.C.
- Bergamaschi I.P.
- Sebastiani A.M.
- et al.
Association between facial measurements and polymorphisms in human epidermal growth
factor and transforming growth factor β1.
Br J Oral Maxillofac Surg. 2020; (pii: S0266-4356(19)30781-8. [Epub ahead of print])https://doi.org/10.1016/j.bjoms.2019.11.024
2
such as ENPP1 and FGFR1.3
Cavalcante et al did not evaluate the effect of these confounding polymorphisms,
and so we think that further studies are necessary.To read this article in full you will need to make a payment
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References
- Association between facial measurements and polymorphisms in human epidermal growth factor and transforming growth factor β1.Br J Oral Maxillofac Surg. 2020; (pii: S0266-4356(19)30781-8. [Epub ahead of print])https://doi.org/10.1016/j.bjoms.2019.11.024
- Genome-wide mapping of global-to-local genetic effects on human facial shape.Nat Genet. 2018; 50: 414-423
- Correlation between facial morphology and gene polymorphisms in the Uygur youth population.Oncotarget. 2017; 8: 28750-28757
Article info
Publication history
Published online: January 28, 2020
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© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
