We would like to congratulate Rajappa et al
1
on publishing their work regarding perineural invasion in early oral cancer. We concur
with their conclusions that perineural invasion is a risk factor for recurrence of
oral cancer. As quoted by the authors themselves, the systematic review by Bur et
al also concluded that adjuvant radiation in early oral cavity cancer in the presence
of perineural invasion as the only risk factor cannot be recommended in view of considerable
limitations in existing publications.
2
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References
- Oncological benefits of postoperative radiotherapy in node-negative early stage cancer of the oral cavity with isolated perineural invasion.Br J Oral Maxillofac Surg. 2019; 57: 454-459
- Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: a systematic review.Head Neck. 2016; 38: E2350-E2357
- Does adverse histopathological features like perineural invasion, depth of invasion and lymphovascular invasion warrant adjuvant treatment in early oral squamous cell carcinoma?.J Head Neck Physicians Surg. 2017; 5: 71-74
US National Library of Medicine. Adjuvant radiotherapy in early stage oral cancers (AREST). Available from URL: https://clinicaltrials.gov/ct2/show/NCT03853655. (last accessed 3 February 2020).
Article info
Publication history
Published online: February 26, 2020
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Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
