Abstract
An impacted third molar is one of the most common dental abnormalities. Among the
reasons for impaction the most common are: insufficient space, time of eruption, improper
position of the tooth bud, and genetic disruptions. To investigate if runt-related
transcription factor 2 (RUNX2), bone morphogenetic protein 2 (BMP2), and msh homeobox
1 (MSX1) are differently expressed depending on the position of the molar, we studied
32 patients who had been referred for surgical removal. An orthopantomogram was used
to separate them according to Winter’s, and Pell & Gregory’s, classifications. Bone
samples were harvested during the operation for gene expression assay. The Kruskal–Wallis,
Dunn’s post hoc, and Spearman’s correlation, tests were used to assess the significance
of differences. No correlations were found in expression of the genes, and no differences
between expression in maxillary and mandibular third molars, nor were they expressed
differently according to Winter’s or Pell and Gregory’s classifications or in relation
to impaction of the mandibular ramus. However, MSX1 was expressed differently when
account was taken of the depth of impaction in maxillary third molars (p = 0.029),
but there was no difference in expression of RUNX2, BMP2, and MSX1 for the Pell and
Gregory classification of depth of impaction (p > 0.05). We conclude that MSX1 is expressed differently depending on the depth of maxillary
impaction phenotypes.
Keywords
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Article info
Publication history
Published online: May 04, 2020
Accepted:
April 4,
2020
Identification
Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
