Abstract
The purpose of this study was to identify thrombin-activatable fibrinolysis inhibitor
(TAFI) in saliva and to investigate the correlation between TAFI levels in saliva
and plasma. Subjects included were healthy adults without diseases or medication that
could affect coagulation. Samples of stimulated saliva and blood samples were obtained
from 33 subjects. Levels of TAFI in saliva and plasma were analysed. The association
between levels of TAFI in saliva and plasma was calculated using linear regression.
Low levels of TAFIa/TAFIai were found in most saliva samples but only one sample had
levels that were above the lower limit of detection of the assay used. TAFI (proenzyme)
was not found in saliva, so no correlations could be calculated. In this study there
was no indication that there is TAFI present in secreted saliva. Either TAFIa/TAFIai
in saliva were much lower than in plasma and under the detection limit of the assay
used, or there was no TAFIa/TAFIai in the saliva tested.
Keywords
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Article info
Publication history
Published online: June 04, 2020
Accepted:
May 13,
2020
Identification
Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
