Abstract
While there have been previous studies examining the relation between the rs17820943
and rs6072081 polymorphisms in the v-maf musculoaponeurotic fibrosarcoma oncogene
homolog B (MAFB) gene and rates of nonsyndromic cleft lip with or without cleft palate
(NSCL/P), at present the results of these studies have been inconsistent. This meta-analysis
therefore aimed to conduct a more robust assessment of the association between the
MAFB rs17820943 and rs6072081 polymorphisms and NSCL/P risk. The Embase, Web of Science,
PubMed, the China National Knowledge Internet (CNKI), and Wanfang databases were systematically
searched to identify relevant studies. In total, five studies incorporating 2769 patients
and 2885 controls were identified assessing the rs17820943 polymorphism and three
studies incorporating 1242 patients and 1310 controls assessing the rs6072081 polymorphism
were identified. This analysis revealed the MAFB rs17820943 and rs6072081 polymorphisms
to be linked to a significantly reduced NSCL/P risk (rs17820943: C vs T: OR = 0.76, 95% CI = 0.70-0.82; CC vs CT: OR = 0.75, 95% CI = 0.67-0.85; CC vs TT: OR = 0.58, 95% CI = 0.49-0.67; CC + CT vs TT: OR = 0.67, 95% CI = 0.59-0.77; CT + TT vs CC: OR = 1.43, 95% CI = 1.28-1.60; rs6072081: A vs G: OR = 0.77, 95%CI = 0.68-0.86; AA vs AG: OR = 0.76, 95%CI = 0.64-0.90; AA vs GG: OR = 0.58, 95%CI = 0.45-0.74; AA + AG vs GG: OR = 0.68, 95%CI = 0.54-0.84; AG + GG vs AA: OR = 1.40, 95% CI = 1.19-1.65). The results of the present meta-analysis indicate that in an East Asian
population, for both rs17820943 and rs6072081 were associated with NSCL/P.
Keywords
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Article info
Publication history
Published online: July 06, 2020
Accepted:
May 20,
2020
Identification
Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
