Advertisement
Research Article| Volume 58, ISSUE 9, e75-e79, November 2020

Spontaneous oral ulceration with bone sequestration: its relevance in current clinical practice

      Abstract

      Oral ulceration associated with bony exposure and sequestration is uncommon and often related to well-recognised conditions. In a small group of patients no obvious aetiological factors can be elucidated, and various terminologies have been utilised to describe these lesions. We report six cases of spontaneous oral ulceration with bone sequestration as a specific entity and review the pertinent literature. We retrospectively reviewed patients presenting in the period 2013-2018. Data collected included demographic details, relevant medical, drug, and radiotherapy history; presentation, investigations, management, and outcome. Six patients with an age range of 49-65 years were identified with spontaneous oral ulceration with bone sequestration in the study period. All were males, and none had any relevant history. Five lesions occurred over the mylohyoid ridge and one was related to a lingual mandibular torus. The most common presentation was a painful ulcer with exposed bone, which had been present for 6 - 12 weeks. Occlusal radiographs demonstrated focal rarefaction in two patients. All were managed conservatively and by removal of the loose sequestrum. Healing occurred successfully in all cases, and this was earlier when the loose sequestrum was removed. Spontaneous oral ulceration with bone sequestration is a distinct lesion that most often presents over the prominence of the mylohyoid ridge. It is currently an uncommon entity (0.02%), but this could well be due to a lack of recognition and under-reporting. It should be considered as a diagnosis only when other causes have been excluded. Lesions heal successfully with conservative management and surgical intervention, and this occurs earlier following removal of the loose sequestrum.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to British Journal of Oral and Maxillofacial Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Shulman J.D.
        • Beach M.M.
        • Rivera-Hidalgo F.
        The prevalence of oral mucosal lesions in the U.S. adults: data from the Third National Health and Nutrition Examination Survey, 1988-1994.
        J Am Dent Assoc. 2004; 135: 1279-1286
        • Almazrooa S.A.
        • Woo S.B.
        Bisphosphonate and nonbisphosphonate-associated osteonecrosis of the jaw: a review.
        J Am Dent Assoc. 2009; 140: 864-875
        • Khan A.A.
        • Morrison A.
        • Hanley D.A.
        • et al.
        Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus.
        J Bone Miner Res. 2015; 30: 3-23
        • Gadiwalla Y.
        • Patel V.
        Osteonecrosis of the jaw unrelated to medication or radiotherapy.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125: 446-453
        • Palla B.
        • Burian E.
        • Klecker J.R.
        • et al.
        Systematic review of oral ulceration with bone sequestration.
        J Craniomaxillofac Surg. 2016; 44: 257-264
        • Peters E.
        • Lovas G.L.
        • Wysocki G.P.
        Lingual mandibular sequestration and ulceration.
        Oral Surg Oral Med Oral Pathol. 1993; 75: 739-743
        • Sonnier K.E.
        • Horning G.M.
        Spontaneous bony exposure: a report of 4 cases of idiopathic exposure and sequestration of alveolar bone.
        J Periodontol. 1997; 68: 758-762
        • Scully C.
        Oral ulceration: a new and unusual complication.
        Br Dent J. 2002; 192: 139-140
        • Friel P.
        • Macintyre D.R.
        Bone sequestration from the 3rd molar region.
        Br Dent J. 2002; 193: 366
        • Farah C.S.
        • Savage N.W.
        Oral ulceration with bone sequestration.
        Aust Dent J. 2003; 48: 61-64
        • Carrad V.C.
        • Sieck G.G.
        • Chaves A.C.
        • et al.
        Oral ulceration with bone sequestration – case report.
        RFOl. 2009; 14: 149-152
        • Thermos G.
        • Kalogirou E.M.
        • Tosios K.I.
        • et al.
        Oral ulceration with bone sequestration: retrospective study of eight cases and literature review.
        Oral Dis. 2019; 25: 515-522
        • Kessler H.P.
        Oral and maxillofacial pathology case on the month. Lingual mandibular sequestration with ulceration.
        Tex Dent J. 2005; 122 (198-9, 206-7)
        • Jackson I.
        • Malden N.
        Lingual mucosal ulceration with mandibular sequestration.
        Dental Update. 2007; 34 (573-4, 576-7)
        • Dhanrajini P.J.
        Lingual mucosal ulceration with mandibular sequestration, Dent Update 2007; 34:573-577.
        Dental Update. 2008; 35: 642
        • Fisher Q.A.
        True, true-but how related? Bone necrosis and sequestration in the mandible after endotracheal intubation.
        Anesth Analg. 2010; 111: 272-273
        • Gündüz K.
        • Özden B.
        • Kurt M.
        • et al.
        Lingual mandibular bone sequestration: a case report.
        J Dent Fac Atatürk Uni. 2010; Suppl 3: 1-4
        • Villa A.
        • Gohel A.
        Oral ulceration with mandibular necrosis.
        J Am Dent Assoc. 2014; 145: 752-756
        • Kharazmi M.
        • Nilsson U.
        • Hallberg P.
        Case report: osteonecrosis as a complication of GA.
        Br Dent J. 2017; 222: 645
        • Cerruto C.
        • Ugolini A.
        • Cozzani M.
        Lingual mandibular osteonecrosis after dental impressions for orthodontic study models.
        Am J Othod Dentofacial Orthop. 2018; 153: 445-448