New World Health Organization classification of odontogenic tumours: impact on the prevalence of odontogenic tumours and analysis of 1231 cases from Turkey


      The aims of this study were to describe the frequency of odontogenic tumours (OT) based on the World Health Organization’s (WHO) 4th edition of Head and Neck Tumours in Turkey, to compare the results with other regions and to assess the frequency changes of OT worldwide after the new WHO classification. OT were selected from the pathology department’s files between 1971-2018. In a total of 1231 OT, 1215 (98.7%) were benign, whereas malignant OT were only 16 cases (1.3%). The three most common tumours were ameloblastoma (n = 366, 29.7%), odontoma (n = 335, 27.2% both complex and compound types), and odontogenic myxoma (n = 190, 15.4%), respectively. After the 2017 classification, the decrease of OT frequency was found among 20%-42% in the selected epidemiological series because of re-classification of some lesions. The pattern of incidence in the Turkish population is similar to that in other populations. However, there are some differences in the frequency of the tumour types. It is obvious that the relative frequency of odontogenic tumours worldwide will change based on the new classification. It should be kept in mind that this is not a real decrease of OT cases. These marked changes in the frequency and prevalence of OT is just related to reclassification of some entities.


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        • Kramer I.R.
        • Pindborg J.J.
        • Shear M.
        The WHO histological typing of odontogenic tumours. A commentary on the second edition.
        Cancer. 1992; 70: 2988-2994
        • Soluk-Tekkeşin M.
        • Wright J.M.
        The World Health Organization classification of odontogenic lesions: a summary of the changes of the 2017 (4th) edition.
        Turk Patoloji Derg. 2018; 34: 1
        • Wright J.M.
        • Vered M.
        Update from the 4th edition of the World Health Organization Classification of Head and Neck Tumors: odontogenic and maxillofacial bone tumours.
        Head Neck Pathol. 2017; 11: 68-77
        • Gaitán-Cepeda L.A.
        • Quezada-Rivera D.
        • Tenorio-Rocha F.
        • et al.
        Reclassification of odontogenic keratocyst as tumour. Impact on the odontogenic tumors prevalence.
        Oral Dis. 2010; 16: 185-187
        • da Silva L.P.
        • Serpa M.S.
        • Tenório J.R.
        • et al.
        Retrospective study of 289 odontogenic tumours in a Brazilian population.
        Med Oral Patol Oral Cir Bucal. 2016; 21: e271-5
        • Ismail S.
        • Saw C.L.
        A clinicopathologic study of 173 odontogenic tumours in Northern Peninsular Malaysia (2007-2014).
        Malays J Pathol. 2018; 40: 129-135
        • Osterne R.L.
        • Brito R.G.
        • Alves A.P.
        • et al.
        Odontogenic tumours: a 5-year retrospective study in a Brazilian population and analysis of 3406 cases reported in the literature.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111: 474-481
        • Servato J.P.
        • Prieto-Oliveira P.
        • de Faria P.R.
        • et al.
        Odontogenic tumours: 240 cases diagnosed over 31 years at a Brazilian university and a review of international literature.
        Int J Oral Maxillofac Surg. 2013; 42: 288-293
        • Jaeger F.
        • de Noronha M.S.
        • Silva M.L.
        • et al.
        Prevalence profile of odontogenic cysts and tumors on Brazilian sample after the reclassification of odontogenic keratocyst.
        J Craniomaxillofac Surg. 2017; 45: 267-270
        • Siriwardena B.S.M.S.
        • Crane H.
        • O’Neill N.
        • et al.
        Odontogenic tumors and lesions treated in a single specialist oral and maxillofacial pathology unit in the United Kingdom in 1992-2016.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2019; 127: 151-166
        • Nalabolu G.R.K.
        • Mohiddin A.
        • Hiremath S.K.S.
        • et al.
        Epidemiological study of odontogenic tumours: An institutional experience.
        J Infect Public Health. 2017; 10: 324-330
        • Siriwardena B.S.
        • Tennakoon T.M.
        • Tilakaratne W.M.
        Relative frequency of odontogenic tumours in Sri Lanka: analysis of 1677 cases.
        Pathol Res Pract. 2012; 208: 225-230
        • Tawfik M.A.
        • Zyada M.M.
        Odontogenic tumours in Dakahlia, Egypt: analysis of 82 cases.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109: e67-73
        • Adebiyi K.E.
        • Ugboko V.I.
        • Omoniyi-Esan G.O.
        • et al.
        Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population.
        Head Face Med. 2006; 2: 42
        • Regezi J.A.
        • Kerr D.A.
        • Courtney R.M.
        Odontogenic tumours: analysis of 706 cases.
        J Oral Surg. 1978; 36: 771-778
        • Daley T.D.
        • Wysocki G.P.
        • Pringle G.A.
        Relative incidence of odontogenic tumours and oral and jaw cysts in a Canadian population.
        Oral Surg Oral Med Oral Pathol. 1994; 77: 276-280
        • Mosqueda-Taylor A.
        • Ledesma-Montes C.
        • Caballero-Sandoval S.
        • et al.
        Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997; 84: 672-675
        • Ochsenius G.
        • Ortega A.
        • Godoy L.
        • et al.
        Odontogenic tumours in Chile: a study of 362 cases.
        J Oral Pathol Med. 2002; 31: 415-420
        • Tamme T.
        • Soots M.
        • Kulla A.
        • et al.
        Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia.
        J Craniomaxillofac Surg. 2004; 32: 161-165
        • Fernandes A.M.
        • Duarte E.C.
        • Pimenta F.J.
        • et al.
        Odontogenic tumours: a study of 340 cases in a Brazilian population.
        J Oral Pathol Med. 2005; 34: 583-587
        • Lu Y.
        • Xuan M.
        • Takata T.
        • et al.
        Odontogenic tumours. A demographic study of 759 cases in a Chinese population.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 86: 707-714
        • Chrysomali E.
        • Leventis M.
        • Titsinides S.
        • et al.
        Odontogenic tumours.
        J Craniofac Surg. 2013; 24: 1521-1525
        • Adebayo E.T.
        • Ajike S.O.
        • Adekeye E.O.
        A review of 318 odontogenic tumours in Kaduna, Nigeria.
        J Oral Maxillofac Surg. 2005; 63: 811-819
        • Luo H.Y.
        • Li T.J.
        Odontogenic tumours: a study of 1309 cases in a Chinese population.
        Oral Oncol. 2009; 45: 706-711
        • Lima-Verde-Osterne R.
        • Turatti E.
        • Cordeiro-Teixeira R.
        • et al.
        The relative frequency of odontogenic tumors: a study of 376 cases in a Brazilian population.
        Med Oral Patol Oral Cir Bucal. 2017; 22: e193-e200
        • Phattarataratip E.
        • Pholjaroen C.
        • Tiranon P.
        A clinicopathologic analysis of 207 cases of benign fibro-osseous lesions of the jaws.
        Int J Surg Pathol. 2014; 22: 326-333
        • Odukoya O.
        Odontogenic tumors: analysis of 289 Nigerian cases.
        J Oral Pathol Med. 1995; 24: 454-457
        • Ladeinde A.L.
        • Ajayi O.F.
        • Ogunlewe M.O.
        • et al.
        Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 99: 191-195
        • Manor Y.
        • Mardinger O.
        • Katz J.
        • et al.
        Peripheral odontogenic tumours--differential diagnosis in gingival lesions.
        Int J Oral Maxillofac Surg. 2004; 33: 268-273
        • Daley T.D.
        • Wysocki G.P.
        Peripheral odontogenic fibroma.
        Oral Surg Oral Med Oral Pathol. 1994; 78: 329-336