Abstract
The present study was a review of cases of central cystadenocarcinoma over the past
29 years and provides clinical, radiological, and pathological information about these
rare lesions. Six cases of central cystadenocarcinoma treated between 1991 and 2019
at Peking University Hospital of Stomatology in Beijing, China, were retrospectively
analysed. A comprehensive review of clinical records was summarised and the histological
diagnosis was revised using the 2017 World Health Organization criteria. The mean
age of patients with central cystadenocarcinoma was 63 (range 51-75) years, and the
male:female ratio 1:1. The clinical signs included localised swelling, pain, lower
lip numbness, and trismus. There were more cases in the mandible than in the maxilla.
All lesions were unilocular or multilocular in radiolucent regions with or without
clear margins. The preferred treatment of central cystadenocarcinoma was surgical
excision with wide margins, and no local recurrence was found during follow-up. Central
cystadenocarcinoma often occurred in middle-aged or elderly patients. Because cystadenocarcinoma
is somewhat rare, metastatic tumours of the jaw should be considered when diagnosing
cystadenocarcinoma.
Keywords
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References
- Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases.Am J Surg Pathol. 1996; 20: 1440-1447
- Histological classification of salivary gland tumours.Histological typing of salivary gland tumors. World Health Organization. 2nd ed. Springer, Berlin1991: 1-38
- Cystadenocarcinoma of salivary gland presenting as a cystic lesion in the mandible.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 201-204
- Cystadenocarcinoma.World Health Organization classification of tumors: pathology and genetics of head and neck tumors. 3rd ed. IARC Lyons, 2005: 74
- Central papillary cystadenocarcinoma of the mandible: A case report and review of the literature.Int J Surg Case Rep. 2014; 5: 330-334
- Central cystadenocarcinoma of the mandible.Int J Oral Maxillofac Surg. 2012; 41: 1463-1466
- Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 cases.J Oral Maxillofac Surg. 2008; 66: 2247-2253
- Cystadenocarcinoma of the mandible.Indian J Dent Res. 2018; 29: 396-399
- Papillary cystadenocarcinoma: report of a case of high-grade histopathologic malignancy.Auris Nasus Larynx. 2007; 34: 259-262
- Update from the 4th Edition of the World Health Organization classification of head and neck tumors: tumors of the salivary gland.Head Neck Pathol. 2017; 11: 55-67
- El-Nagger A.K. Grandis J.R. Takata T. WHO classification of head and neck tumors. 4th ed. IARC, Lyon2017
- Orofacial and mandibular reconstruction with the iliac crest free flap: a review of 60 cases and a new method of classification.Plast Reconstr Surg. 1989; 84: 391-405
- Central salivary gland tumors of the maxilla and mandible: A clinicopathologic study of 11 cases with an analysis of the literature.J Oral Maxillofac Surg. 1992; 50: 229-236
- Intraosseous salivary tissue: Jawbone examples of choristomas, hamartomas, embryonic rests, and inflammatory entrapment : Another histogenetic source for intraosseous adenocarcinoma.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 90: 205-217
- Central mucoepidermoid carcinoma of the mandible: report of four cases with long-term follow-up.Int J Oral Maxillofac Surg. 2003; 32: 378-382
- Other carcinomas.Histopathology of the salivary glands. Springer, New York2014: 375-427
- Benign jaw tumors and tumorlike conditions.Maxillofacial imaging. Springer International, New York2018: 57-70
- Malignant tumors in jaws.Maxillofacial imaging. Springer International, New York2018: 171
- Cystadenocarcinoma of the salivary glands.in: Volavšek M. Head and neck pathology. Springer International, New York2016: 92-95
- Cystadenoma of the salivary glands.in: Volavšek M. Head and neck pathology. Springer International, New York2016: 95-98
- Mucoepidermoid carcinoma of the salivary glands.in: Volavšek M. Head and neck pathology. Springer International, New York2016: 238-241
- Acinic cell carcinoma of the salivary glands.in: Volavšek M. Head and neck pathology. Springer International, New York2016: 7-10
- Major salivary glands.in: Edge S.B. AJCC AJCC cancer staging manual. 8th ed. Springer International, 2017: 95
- Bone.in: Edge S.B. AJCC AJCC cancer staging manual. 8th ed. Springer International, 2017: 473-477
Article info
Publication history
Published online: July 13, 2020
Accepted:
June 29,
2020
Identification
Copyright
© 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
