Malignant transformation in a cohort of patients with oral epithelial dysplasia


      Oral epithelial dysplasia (OED) is often diagnosed in oral potentially malignant disorders (OPMD) and carries an increased risk of malignant transformation. Currently, the reported risk of malignant transformation for OED varies. Here we present the risk in a cohort of 150 patients with OED at a specialist centre. In this cohort 2.6%, 4.1%, and 29.2% cases of mild, moderate, and severe OED, respectively, progressed to oral squamous cell carcinoma at the dysplastic site, while a small number developed a malignant lesion elsewhere. Moreover, 17 patients experienced an increase in grade of dysplasia and two showed histological resolution of their lesions.


      To read this article in full you will need to make a payment


        • Iocca O.
        • Sollecito T.P.
        • Alawi F.
        • et al.
        Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype.
        Head Neck. 2020; 42: 539-555
        • Speight P.M.
        • Khurram S.A.
        • Kujan O.
        Oral potentially malignant disorders: risk of progression to malignancy.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2018; 125: 612-627
        • Mehanna H.M.
        • Rattay T.
        • Smith J.
        • et al.
        Treatment and follow-up of oral dysplasia - a systematic review and meta-analysis.
        Head Neck. 2009; 31: 1600-1609
        • Warnakulasuriya S.
        • Kovacevic T.
        • Madden P.
        • et al.
        Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England.
        J Oral Pathol Med. 2011; 40: 677-683
        • Warnakulasuriya S.
        • Ariyawardana A.
        Malignant transformation of oral leukoplakia: a systematic review of observational studies.
        J Oral Pathol Med. 2016; 45: 155-166
        • Reibel J.
        • Gale N.
        • Hille J.
        • et al.
        Oral potentially malignant disorders and oral epithelial dysplasia.
        in: El-Naggar A.K. Chan J.K. Grandis J.R. WHO classification of head and neck tumours. 4th ed. IARC, 2017: 112-114
        • Ho M.W.
        • Field E.A.
        • Field J.K.
        • et al.
        Outcomes of oral squamous cell carcinoma arising from oral epithelial dysplasia: rationale for monitoring premalignant oral lesions in a multidisciplinary clinic.
        Br J Oral Maxillofac Surg. 2013; 51: 594-599
        • Bouquot J.E.
        • Speight P.M.
        • Farthing P.M.
        Epithelial dysplasia of the oral mucosa—diagnostic problems and prognostic features.
        Curr Diagn Pathol. 2006; 12: 11-21
        • Ho M.W.
        • Risk J.M.
        • Woolgar J.A.
        • et al.
        The clinical determinants of malignant transformation in oral epithelial dysplasia.
        Oral Oncol. 2012; 48: 969-976
        • Dost F.
        • Lê Cao K.
        • Ford P.J.
        • et al.
        Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117: 343-352