Abstract
The aim of this review was to assess the level of evidence for genetic, biological,
and functional predictive and predisposing factors for end-stage temporomandibular
joint arthritis within the published literature. A comprehensive review based upon
PRISMA guidelines was performed from all literature relevant to the topic. Case series
and animal studies were included given the rare nature of the disease and goal of
finding root-cause predictive factors. Clinical and radiographic measures were used
specifically to identify factors which may have contributed to disease onset and progression.
A total of 249 abstracts were identified based on search terms of major databases.
After application of exclusion and inclusion criteria, 63 full-text articles were
included in the analysis of this paper. There were few factors that could be reliably
used to predict end-stage temporomandibular joint disease. Limited evidence is available
to adequately predict end-stage temporomandibular joint osteoarthritis. No descriptive
process exists that explains how and why this process can occur in younger adults.
A better understanding of the aetiology and pathogenesis of TMJ-OA may lead to prevention
and more effective management strategies that may reduce the need for drastic surgical
intervention, particularly in young adults.
Keywords
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Article info
Publication history
Published online: July 29, 2021
Accepted:
June 11,
2021
Identification
Copyright
© 2021 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
