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Allergy to Penicillin and Rheumatoid Arthritis: A link that could play a role in the risk of implant failure

Published:February 05, 2022DOI:https://doi.org/10.1016/j.bjoms.2022.01.013
      In recent years, literature has shown that patients allergic to penicillin have significantly higher rates of implant failure than non-allergic patients. A cross-sectional study by Salomó-Coll et al.,
      • Salomó-Coll O.
      • Lozano-Carrascal N.
      • Lázaro-Abdulkarim A.
      • et al.
      Do penicillin-allergic patients present a higher rate of implant failure?.
      with a sample of 1,210 patients, found that penicillin-allergic patients had 3.8-times higher risk of implant failure compared with non-allergic patients. Similarly, French et al.
      • French D.
      • Noroozi M.
      • Shariati B.
      • et al.
      Clinical retrospective study of self-reported penicillin allergy on dental implant failures and infections.
      performed a retrospective study evaluating the survival and infection complications of 5,576 implants. The odds ratio of failure for implants placed in penicillin-allergic patients were 3.1-times higher than in non-allergic patients, and they further increased to 10-times higher failure rate for immediate implants. These findings were statistically significant.
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      References

        • Salomó-Coll O.
        • Lozano-Carrascal N.
        • Lázaro-Abdulkarim A.
        • et al.
        Do penicillin-allergic patients present a higher rate of implant failure?.
        Int J Oral Maxillofacial Implants. 2018; 33: 1390-1395
        • French D.
        • Noroozi M.
        • Shariati B.
        • et al.
        Clinical retrospective study of self-reported penicillin allergy on dental implant failures and infections.
        Quintessence Int. 2016; 47: 861-870
        • Krebs K.
        • Bovijn J.
        • Zheng N.
        • et al.
        Genome-wide study identifies association between HLA-B∗55:01 and self-reported penicillin allergy.
        Am J Human Genetics. 2020; 107: 612-621
        • Raslan H.M.
        • Attia H.R.
        • Salama I.
        • et al.
        Association of PTPN22 1858C→T polymorphism, HLA-DRB1 shared epitope and autoantibodies with rheumatoid arthritis.
        Rheumatol Int. 2016; 36: 1167-1175
        • Nagy R.
        • Szabo K.
        • Szucs A.
        • et al.
        Impact of rheumatoid arthritis in oral surgery and implantology treatment based on literature.
        Fogorv Sz. 2017; 110: 3-6