Effects of photobiomodulation therapy on implant stability and postoperative recovery: a systematic review and meta-analysis

  • Changxing Qu
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China
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  • Feng Luo
    Corresponding author at: Department of Prosthodontics, West China School of Stomatology, Sichuan University, No. 14, Section 3, Renmin Nanlu, Chengdu 610041, China.
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China
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  • Guang Hong
    Liaison Center for Innovative Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan

    Department of Prosthetic Dentistry, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia
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  • Qianbing Wan
    State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China
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Published:February 05, 2022DOI:


      The purpose of this study was to systemically analyse the effects of photobiomodulation therapy (PBMT) on implant stability and postoperative recovery. Electronic searches on MEDLINE (PubMed), Cochrane Library, EMBASE, and Web of Science were completed independently by two researchers in February 2021, and a manual search was performed for the references of the included articles. The primary outcome was implant stability. The secondary outcome was postoperative recovery, including postoperative pain, recovery of peri-implant hard tissue (marginal bone loss and bone mineral density), facial swelling, and peri-implant clinical parameters. Twenty studies were finally obtained (17 randomised controlled, and 3 controlled clinical studies). Meta-analysis revealed that PBMT increased implant stability at 10 days after insertion (MD 2.27, 95% CI: 0.40 to 4.13, P = 0.020), and reduced marginal bone loss at 6 months after insertion (MD −0.16, 95% CI: −0.23 to −0.08, P < 0.001). However, no significant improvements were noted in implant stability two weeks (P = 0.070), three weeks (P = 0.090), six weeks (P = 0.050), and 12 weeks (P = 0.080) after insertion. Qualitative analysis suggested that PBMT could not alleviate postoperative pain, increase bone mineral density, or improve peri-implant clinical parameters. It was effective only in reducing facial swelling. This study suggests that the effects of PBMT on implant stability and postoperative recovery may be limited.


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