Abstract
Salivary gland tumours (SGT) demonstrate geographical variation. The primary objective
of this study was to determine the types, frequency, distribution, and demographics
of non-neoplastic and neoplastic salivary gland pathology at Waikato Hospital, New
Zealand (NZ) over a 10-year period. Following this we conducted a 10-year retrospective
review of SGT epidemiology from international literature. In total 825 patients were
identified, 31% (256/825) with non-neoplastic salivary gland pathology, 34% (284/825)
with benign neoplastic pathology, 14% (118/825) with primary malignant lesions, 18%
(146/825) with metastatic SGTs, and 3% (21/825) with lymphoma. Patients had a mean
(range) age of 58 (3–102) years, were predominantly male (58%, 476/825), and NZ European
(65%, 536/825). Tumours were most prevalent in the parotid gland (85%, 484/569), of
which 44% (211/484) were malignant. Pleomorphic adenoma was the most common benign
(71%, 203/284) and overall (36%, 203/569) tumour, while mucoepidermoid carcinoma (25%,
29/118) and squamous cell carcinoma (SCC) (73%, 106/146) were the most common primary
malignant and metastatic SGTs, respectively. Our literature review identified 18 studies
consisting of 33,933 patients, of whom 71% (24,013/33,933) had benign SGTs. Pleomorphic
adenoma (68%, 16404/24013) and mucoepidermoid carcinoma (29%, 2826/9621) were the
most common benign and malignant SGTs, respectively. Low numbers of non-neoplastic
and metastatic SGTs were reported in the literature. This research provides a greater
understanding of differences in their global distribution. Consistent with previous
literature, pleomorphic adenoma and mucoepidermoid carcinoma were the most common
benign and malignant SGTs. In NZ, we found high rates of malignant SCC to the parotid
gland, consistent with the epidemiology of non-melanoma skin cancer in the country.
Keywords
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References
- Management of malignant tumors of the salivary glands.Oncology (Williston Park). 1998; 12 (discussion 683): 671-680
- Review of salivary gland neoplasms.ISRN Otolaryngol. 2012; 2012872982
- A review of selected factors of salivary gland tumour formation and malignant transformation.Biomed Res Int. 2018; (Epub ahead of print)https://doi.org/10.1155/2018/2897827
- El-Naggar A.K. Chan J.K. Grandis J.R. WHO classification of head and neck tumours: WHO classification of tumours. 4th ed. IARC Press, 2017
- Salivary gland tumours: diagnostic challenges and an update on the latest WHO classification.Diagn Histopathol. 2020; 26: 147-158
- Salivary gland tumours in Iceland 1986–2015: a nationwide epidemiological analysis over a 30-year time period.APMIS. 2021; 129: 55-60
- Clinical analysis of salivary gland tumor cases in West China in past 50 years.Oral Oncol. 2008; 44: 187-192
- Contemporary treatment patterns and outcomes of salivary gland carcinoma: a National Cancer Database review.Eur Arch Otorhinolaryngol. 2019; 276: 1135-1146
- Tumours of the salivary glands: a histological and clinical review.Br J Oral Surg. 1979; 17: 47-56
- Non-neoplastic salivary gland lesions: a 15-year study.Eur Arch Otorhinolaryngol. 2011; 268: 1187-1190
- Epidemiology of primary epithelial salivary gland tumors in Southern Poland—a 26-year, clinicopathologic, retrospective analysis.J Clin Med. 2021; 10: 1663
- Management of salivary gland tumours: United Kingdom National Multidisciplinary Guidelines.J Laryngol Otol. 2016; 130: S142-S149
- Salivary gland tumors: a clinicopathologic study of 366 cases in southern Iran.Asian Pac J Cancer Prev. 2013; 14: 27-30
- Barnes L. Everson J.W. Reichart P. Pathology and genetics of head and neck tumours: WHO classification of tumours. 3rd ed. IARC Press, 2005
- Salivary gland tumors: a clinicopathologic analysis from Taipei Veterans General Hospital.Ann Plast Surg. 2020; 84: S26-S33
- Epidemiological profile of salivary gland lesions diagnosed in a higher education institution: an observational and retrospective study of 381 cases.Acta Scientiarum Health Sci. 2020; 42e51032
- Descriptive epidemiology of salivary gland neoplasms in Nigeria: an AOPRC multicenter tertiary hospital study.Oral Dis. 2019; 25: 142-149
- Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population.Oral Surg Oral Med Oral Pathol Oral Radiol. 2012; 114: 230-239
- Salivary gland tumors in a Brazilian population: a retrospective study of 496 cases.Int J Oral Maxillofac Surg. 2005; 34: 533-536
- Salivary gland tumor: a review of 599 cases in a Brazilian population.Head Neck Pathol. 2009; 3: 271-275
- Salivary gland tumours in a northern Chinese population: a 50-year retrospective study of 7190 cases.Int J Oral Maxillofac Surg. 2017; 46: 343-349
- Demographics of benign parotid tumours: Warthin’s tumour versus other benign salivary tumours.Acta Otolaryngol. 2016; 136: 83-86
- Incidence of salivary gland neoplasms in a defined UK population.Br J Oral Maxillofac Surg. 2013; 51: 399-403
- Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.Int J Oral Maxillofac Surg. 2010; 39: 235-242
- Incidence and prevalence of non-melanoma skin cancer in Australia: a systematic review.Australas J Dermatol. 2015; 56: 258-267
- The burden of non-melanoma skin cancers in Auckland, New Zealand.Australas J Dermatol. 2018; 59: 210-213
- Cutaneous squamous cell carcinoma metastatic to parotid-area lymph nodes.Laryngoscope. 2008; 118: 1989-1996
- Metastatic cutaneous squamous cell carcinoma of the parotid gland: prognostic factors.J Laryngol Otol. 2018; 132: 264-269
- Evaluation of 242 consecutive parotidectomies performed for benign and malignant disease.Aust N Z J Surg. 1993; 63: 870-877
- Trends in parotidectomy over 30 years in an Australian tertiary care center.Head Neck. 2020; 42: 2905-2911
- Management of salivary gland tumors in a Nigerian tertiary institution.Ann Afr Med. 2015; 14: 148-154
- Survival after parotid gland metastases of cutaneous squamous cell carcinoma of the head and neck.Oral Maxillofac Surg. 2021; 25: 383-388
- Primary epithelial minor salivary gland tumors in South Africa: a 20-year review.Head Neck Pathol. 2020; 14: 715-723
- Major and minor salivary gland tumours.Crit Rev Oncol Hematol. 2020; 152102595
- Types of sublingual gland herniation observed during sonography of plunging ranulas.J Ultrasound Med. 2014; 33: 1491-1497
- Plunging ranulas and prevalence of the “tail sign” in 126 consecutive cases.J Ultrasound Med. 2020; 39: 273-278
- Plunging ranula: congenital or acquired?.Otolaryngol Head Neck Surg. 2010; 142: 104-107
- Salivary gland diseases: infections, sialolithiasis and mucoceles.Monogr Oral Sci. 2014; 24: 135-148
- A survey on 245 patients and a review of the literature.Int J Oral Maxillofac Surg. 1990; 19: 135-138
Article info
Publication history
Published online: December 09, 2022
Accepted:
November 1,
2022
Received in revised form:
September 26,
2022
Received:
July 21,
2022
Identification
Copyright
© 2022 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
