Abstract
Carnoy’s solution, a chemical cauterisation agent, has been indicated as one of the
adjuvant treatment modalities for odontogenic keratocyst. In 2000, after the ban of
chloroform many surgeons adopted the use of Modified Carnoy’s solution. The purpose
of this study is to compare the depth of penetration and amount of bone necrosis of
Carnoy’s versus Modified Carnoy’s solution on the mandible of Wistar rats at different
time intervals. Twenty-six male Wistar rats of six to eight weeks old, weighing approximately
150–200 grams, were allocated for this study. The predictor variables were type of
solution and application time. The outcome variable was depth of penetration and amount
of bone necrosis. Carnoy’s solution was applied on the defect on the right side of
the mandible and Modified Carnoy’s solution on the left side for five minutes on eight
rats, eight minutes on eight rats, and 10 minutes on eight rats. All specimens were
subjected to histomorphometric analysis done using Mia image AR software. Univariate
ANOVA test, and paired sample t test was done to compare the results. The depth of penetration for Carnoy’s solution
was more than Modified Carnoy’s solution in the three different exposure times. Statistically
significant results were observed at five minutes and eight minutes. The amount of
bone necrosis was more in Modified Carnoy’s solution. The results were not statistically
significant at the three different exposure times. To conclude, when one wants to
use Modified Carnoy’s solution, the minimum exposure time should be 10 minutes to
achieve similar results as those of Carnoy’s solution.
Keywords
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Article info
Publication history
Published online: March 02, 2023
Accepted:
February 27,
2023
Received in revised form:
February 17,
2023
Received:
August 31,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
